遠(yuǎn)志為遠(yuǎn)志科植物遠(yuǎn)志Polygala tenuifolia或卵葉遠(yuǎn)志P. sibirica的干燥根,藥用歷史悠久。現(xiàn)代研究表明,遠(yuǎn)志具有神經(jīng)保護(hù)、抗氧化、抗腫瘤、抗抑郁、改善認(rèn)知功能障礙及鎮(zhèn)靜催眠等藥理活性,其炮制工藝與藥效關(guān)聯(lián)性已成為研究熱點(diǎn)。然而,目前尚缺乏對(duì)遠(yuǎn)志古今功效關(guān)聯(lián)性及整體藥理作用的系統(tǒng)分析。通過文獻(xiàn)計(jì)量學(xué)方法,結(jié)合本草典籍考證、《中國(guó)藥典》2025年版成方制劑分析及CiteSpace可視化技術(shù),系統(tǒng)梳理了遠(yuǎn)志的傳統(tǒng)功效與現(xiàn)代藥理活性研究,為遠(yuǎn)志的深入研究和臨床應(yīng)用提供參考。

Yuanzhi (Polygalae Radix) refers to the dried root of Polygala tenuifolia or P. sibirica, which belongs to Polygalaceae family. It has a long history of medicinal use. Modern research indicates that Polygalae Radix exhibits various pharmacological activities, such as neuroprotective, antioxidant, antitumor, antidepressant, cognitive-enhancing, and sedative-hypnotic effects. The relationship between its processing methods and efficacy has become a current research focus. However, there remains a lack of systematic analysis on the correlation between its traditional and modern effects of Polygalae Radix and its overall pharmacological effects. This study employs bibliometric methods, textual research on ancient materia medica texts, analytical result of formulated preparations from the Chinese Pharmacopoeia (2025 edition), and CiteSpace visualization technology to systematically review the traditional uses and modern pharmacological activities of Polygalae Radix. These findings aim to provide a theoretical reference for further research and clinical application.

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蘇州市科技計(jì)劃項(xiàng)目（SKY2021019）；常熟市衛(wèi)生健康委員會(huì)科技計(jì)劃項(xiàng)目（CSWS202120）；天津市科技計(jì)劃項(xiàng)目（24ZYJDSS00300）；現(xiàn)代中藥新質(zhì)生產(chǎn)力科技創(chuàng)新工程專項(xiàng)（24ZXZKSY00010）