目的 低灌注性腦梗死(hypoperfusion cerebral infarction,HCI)是腦梗死的重要亞型,其當(dāng)前治療方案存在一定局限性。通過整合多源異構(gòu)數(shù)據(jù)庫及測量網(wǎng)絡(luò)模塊距離的方法為參麥注射液(Shenmai Injection,SMI)治療HCI提供證據(jù)支持。方法 采用3種不同的方法在開源數(shù)據(jù)庫中獲取HCI的疾病靶點。通過在蛋白質(zhì)互作網(wǎng)絡(luò)中比較SMI、常規(guī)化學(xué)藥、中成藥與疾病靶點的S_AB、Z值,探索SMI治療HCI的潛力;通過“靶點-成分-中藥”路徑,結(jié)合PageRank與Hscore方法驗證SMI藥物組成在治療HCI中藥推薦中的排名情況。結(jié)果 與常規(guī)化學(xué)藥相比,治療腦梗死的中成藥S_AB、Z值普遍較小;與其他中成藥相比,SMI的S_AB值在疾病靶點整合方法2(數(shù)據(jù)集2、數(shù)據(jù)集3)中排名靠前,在其余疾病靶點整合方法中的距離優(yōu)勢未凸顯出來。687味中藥推薦排名結(jié)果發(fā)現(xiàn),在整合的4個不同的數(shù)據(jù)集中,紅參排名均排在前20名,麥冬排名在前302名以內(nèi)。結(jié)論 SMI可能在治療HCI尤其是慢性心系疾病導(dǎo)致的HCI方面具有一定優(yōu)勢。其作用機制除了直接促進腦組織修復(fù)和再生外,還涉及流體剪切應(yīng)力與動脈粥樣硬化通路,可能與通過改善心臟泵血能力而間接達到增加腦灌注的作用有關(guān)。

Objective Hypoperfusion cerebral infarction (HCI) represents a critical subtype of cerebral infarction, for which current therapeutic strategies exhibit notable limitations. To provide evidence supporting Shenmai Injection (SMI, 參麥注射液)’s efficacy in HCI treatment by integrating multi-source heterogeneous databases and employing network module distance measurement methodologies. Methods Disease targets for HCI were identified using three distinct approaches in open-source databases. The therapeutic potential of SMI was evaluated by comparing its S_AB and Z-scores with those of conventional Western drugs and Chinese patent medicines within a protein-protein interaction network, followed by validation of SMI’s prioritized ranking in HCI treatment through a “target-component-herb” pathway analysis integrating PageRank and Hscore algorithms. Results Compared to conventional Western drugs, Chinese patent medicines for cerebral infarction showed generally lower S_AB and Z-values. Compared with other Chinese patent medicines, SMI demonstrated superior performance (lower S_AB values) in two target-integration methods (Datasets 2 and 3), though this advantage was not consistently observed across all analytical approaches. Among 687 herbs analyzed, Hongshen (Ginseng Radix et Rhizoma Rubra) consistently ranked top 20 in all four datasets, while Maidong (Ophiopogonis Radix) appeared within the top 302. Conclusion SMI may offer particular therapeutic advantages for HCI, especially in cases secondary to chronic cardiac conditions. Its mechanism appears multifactorial, involving not only direct neurorestorative effects but also modulation of fluid shear stress and atherosclerosis pathways, potentially mediated through improved cardiac output and subsequent cerebral perfusion enhancement.

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中央級公益性科研院所基本科研業(yè)務(wù)費專項資金資助（ZZ1718-XRZ-105-SJ）；中國中醫(yī)科學(xué)院科技創(chuàng)新工程（CI2021A05042）