缺血性腦卒中（ischemic stroke，IS）是由腦動脈或頸動脈堵塞引起局部腦組織缺血缺氧的急性血管疾病，具有高發(fā)病率、高死亡率和高致殘率的特點，嚴重威脅中老年群體的身體健康和生活質(zhì)量。目前，溶栓和取栓術(shù)是治療IS的常用方法，但仍有部分患者因各種原因無法接受此類血管再通治療。近年來的研究表明，中藥活性成分在IS治療中展現(xiàn)出良好效果，相關(guān)研究也日益受到重視。通過綜述IS的病理發(fā)展過程及中藥活性成分改善IS的具體作用機制，為缺血性腦卒中的臨床治療策略及中藥活性成分的開發(fā)提供研究思路和參考。

Ischemic stroke (IS) is an acute cerebrovascular disease caused by blockage of cerebral or carotid arteries, leading to localized cerebral ischemia and hypoxia. It is characterized by high incidence, mortality, and disability rates, posing a serious threat to the health and quality of life of middle-aged and elderly populations. Currently, thrombolysis and thrombectomy are common methods for IS. However, a considerable number of patients are unable to undergo such vascular recanalization therapies due to various reasons. Recent research has shown that many active ingredients of traditional Chinese medicine (TCM) exhibit promising therapeutic effects in the prevention and treatment of IS, garnering increasing attention. This review summarizes the pathological progression of IS and the specific mechanisms by which TCM active components alleviate IS, providing new insights and references for clinical therapeutic strategies and development of TCM-based interventions for IS.

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國家中醫(yī)藥多學科交叉創(chuàng)新團隊項目（ZYYCXTD-D-202004）