炎癥性腸?。╥nflammatory bowel disease，IBD）發(fā)病機(jī)制復(fù)雜，且在臨床上表現(xiàn)出長(zhǎng)期性、反復(fù)性的特點(diǎn)，對(duì)患者身心健康造成一定程度的不良影響。葛根Puerariae Lobatae Radix作為傳統(tǒng)的藥食同源中藥，其化學(xué)成分多樣，包括（異）黃酮類、有機(jī)酸類、萜類、香豆素類、甾體類及其他活性組分，具有解肌退熱、升陽(yáng)止瀉等功效?，F(xiàn)代藥理學(xué)研究證實(shí)葛根及其有效成分在抗炎、抗氧化、調(diào)節(jié)免疫等多方面發(fā)揮治療作用，對(duì)IBD的治療具有多途徑、多靶點(diǎn)的優(yōu)勢(shì)。新型復(fù)合材料的研發(fā)，有助于解決葛根素等活性成分口服生物利用度差等問(wèn)題，使葛根在IBD的臨床應(yīng)用上獲得更多可能。通過(guò)對(duì)近年來(lái)葛根及其有效成分治療IBD的作用機(jī)制和應(yīng)用進(jìn)行綜述，為葛根在IBD的臨床使用提供一定參考。

Inflammatory bowel disease (IBD) has a complex pathogenesis and often exhibits a long-term, recurrent pattern, which adversely affects patients’ physical and mental health. Gegen (Puerariae Lobatae Radix), a traditional herb with medicinal and edible properties, has diverse chemical components, including (iso) flavonoids, organic acids, terpenes, coumarins, steroids, and other active components, which have functions such as relieving muscle spasms, reducing fever, promoting yang, and stopping diarrhea. Modern pharmacological studies have confirmed that Puerariae Lobatae Radix and its active components exert therapeutic effects in anti-inflammation, antioxidation, and immune regulation, which provide multi-pathway and multi-target therapeutic advantages in the treatment of IBD. The development of novel composite materials can help solve the problem of poor oral bioavailability of active components such as puerarin, which can increase the potential for the clinical application of Puerariae Lobatae Radix in IBD. This review summarizes the recent advances in treatment of IBD with Puerariae Lobatae Radix and its active components, and discusses their mechanisms of action and applications, with the aim of providing a reference for the clinical use of Puerariae Lobatae Radix in IBD.

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國(guó)家中醫(yī)臨床研究基地科研專項(xiàng)（2021JDZX066）;河南省中醫(yī)藥科學(xué)研究專項(xiàng)（2022ZY1043）