中藥七情是中藥配伍的主要形式。代謝組學(xué)主要研究代謝譜差異，通過分析代謝物以及代謝通路與生理病理變化的相對(duì)關(guān)系，闡釋藥物的作用機(jī)制，分析配伍用藥的作用關(guān)系。通過歸納近年來運(yùn)用代謝組學(xué)分析中藥單行、相須、相使、相畏、相殺、相惡、相反7種配伍方式產(chǎn)生的增效、減毒、藥性變化及作用機(jī)制，為客觀地闡釋中藥七情配伍應(yīng)用的合理性提供依據(jù)。

Seven emotions of Chinese materia medica (CMM) is the main compatibility form. Metabonomics is mainly to study the differences of metabolic spectrum, analyze the relationship between pathway and physiological and pathological changes of organisms after drug use through the analysis of metabolites, and explain the mechanism of drug action and the function relationship of compatible drugs. The author summarized the characteristics of increasing efficiency, detoxification, drug property changes and action mechanism from the compatibility forms of using a single drug, mutual reinforcement, mutual assistance, mutual restraint, mutual suppression, mutual inhibition and antagonism in the application of CMM by using metabonomics in recent years, in order to provide a basis for the objective interpretation of the compatibility of seven emotions of CMM.

國(guó)家自然科學(xué)基金（地區(qū)）項(xiàng)目（81360633）；蘭州市科技局項(xiàng)目（2018-4-63）；甘肅省中藥藥理與毒理重點(diǎn)實(shí)驗(yàn)室開放基金項(xiàng)目（ZDSYS-KJ-2018-009）