目的 比較醒腦靜不同制劑給大鼠鼻單向灌流后其有效成分龍腦和麝香酮吸收特征。方法 采用大鼠在體鼻單向灌流模型，GC法測(cè)定灌流液中龍腦和麝香酮的量，比較醒腦靜滴鼻液與醒腦靜微乳中龍腦和麝香酮在大鼠鼻腔的吸收。結(jié)果醒腦靜滴鼻液中龍腦吸收速率常數(shù)（K_a）為（1.00±0.02）min^?1，醒腦靜微乳中龍腦K_a為（0.76±0.03）min^?1；醒腦靜滴鼻液中麝香酮K_a為（0.76±0.02）min^?1，醒腦靜微乳中麝香酮K_a為（0.58±0.10）min^?1。結(jié)論 醒腦靜滴鼻液中龍腦和麝香酮在鼻腔的吸收均較醒腦靜微乳快。

Objective To compare the absorption characteristics of Luodian Borneolum and muscone after nasal unidirectional perfusion with different Xingnaojing preparations in rats. Methods The nasal unidirectional perfusion model was used, the contents of Luodian Borneolum and muscone were determined by GC method, and the absorption of Luodian Borneolum and muscone in Xingnaojing Nasal Drop (XN) and Xingnaojing Microemulsion (XM) were compared. Results The absorption rate constants (K_a) of Luodian Borneolum in XN and XM were (1.00 ± 0.02) and (0.76 ± 0.03) min^?1, respectively, and the K_a values of muscone in XN and XM were (0.76 ± 0.02) and (0.58 ± 0.10) min^?1, respectively. Conclusion The absorption of Luodian Borneolum and muscone in XN are both faster than that in XM.

國(guó)家自然科學(xué)基金面上項(xiàng)目（81073057）；國(guó)家自然科學(xué)基金青年科學(xué)基金資助項(xiàng)目（81102816）