觀察了麝香保心丸對心肌組織內(nèi)皮型一氧化氮合酶(eNOS)的表達及左室功能的影響。在大鼠心梗模型上治療組給予麝香保心丸33mg/d 2或 6周,用心導(dǎo)管測定心臟功能,免疫組織化學(xué)法測定心肌 eNOS水平,結(jié)果表明：麝香保心丸可同時增加心肌 eNOS的表達水平、改善心梗后左室收縮及舒張功能。

Effects of heart protecting musk pill (HMP),a traditional medical preparation for the treatment of myocardial infarction, on the expression of myocardial endothelial NO synthase (eNOS) and left ventricular function of acute myocardial infarcition (AMI) rat model were studied. AMI rat models were prepared by coronary artery ligation and randomized into 4 groups:Two groups of AMI-2 and AMI-6 were kept as controls,and the other two, were treated with HMP 33 mg/d by intubation for 2 weeks (HMP-2) or 6 weeks (HMP-6). Cardiac functions (LVESP, LVEDP, dp/dtmax,dp/dtmin) were measured at the end of 2nd and sixth week of treatment with left ventricular catheter insertion. The level of myocardial eNOS were measured by immunohistochemical staining and image analysis. Results showed that the 2 HMP treated groups resulted in an increase of expression of myocardial eNOS CP<0. 05) and an improved systolic, and diastolic functions of left ventricular at the end of 2nd and sixth week of treatment as compared with the control (P<0. 05).It may be concluded that HMP can increase the level of myocardial eNOS and improve cardiac functions after myocardial infarction at the same time.

上海市科委基金