目的 對燈盞細辛注射液聯(lián)合常規(guī)藥物治療糖尿病周圍神經(jīng)病變臨床療效和安全性進行系統(tǒng)評價。方法 計算機檢索中國學(xué)術(shù)期刊全文數(shù)據(jù)庫（CNKI）、中國生物醫(yī)學(xué)文獻數(shù)據(jù)庫（CBM）、維普中文科技期刊數(shù)據(jù)庫（VIP）、萬方醫(yī)學(xué)期刊全文數(shù)據(jù)庫、PubMed、Embase、Cochrane library等數(shù)據(jù)庫，檢索日期截止到2018年8月19日。根據(jù)Cochrane系統(tǒng)評價的方法進行納入研究的篩選，提取數(shù)據(jù)和質(zhì)量評價，然后采用Revman 5.3軟件進行Meta-分析。結(jié)果 共有23項研究最終進入本系統(tǒng)評價，Meta-分析結(jié)果顯示燈盞細辛注射液聯(lián)合常規(guī)治療組患者的臨床有效率明顯優(yōu)于單純常規(guī)治療組（RR=1.42，95% CI=1.28~1.57，P<0.000 01）；在尺神經(jīng)運動神經(jīng)傳導(dǎo)速度、腓神經(jīng)運動神經(jīng)及感覺神經(jīng)傳導(dǎo)速度、正中神經(jīng)運動神經(jīng)及感覺神經(jīng)傳導(dǎo)速度改善方面，燈盞細辛注射液聯(lián)合常規(guī)藥物優(yōu)于單純常規(guī)藥物治療。在尺神經(jīng)感覺神經(jīng)傳導(dǎo)速度改善方面，兩組比較無統(tǒng)計學(xué)差異。結(jié)論 燈盞細辛注射液聯(lián)合常規(guī)藥物比單純常規(guī)藥物治療在改善糖尿病周圍神經(jīng)病變臨床結(jié)局上更有優(yōu)勢。

Objective Systematic evaluation of clinical efficacy and safety of Dengzhan Xixin Injection combined with conventional drugs in the treatment of diabetic peripheral neuropathy. Methods Computer retrieval of CNKI, CBM, VIP, Wanfang Database, PubMed, Embase, Cochrane library was conducted until August 19, 2018. The methods of Cochrane systematic evaluation were used to screen the included studies, extract data and do quality evaluation, and Revman 5.3 software was then used for Metaanalysis. Results A total of 23 studies were finally included in the system evaluation, and the results of Meta-analysis showed that the clinical efficiency of patients in the Dengzhanxixin Injection combined with conventional treatment group was significantly superior to that in the simple conventional treatment group (RR=1.42, 95%CI=1.28-1.57, P<0.000 01). In the improvement of ulnar nerve motor conduction velocity, peroneal nerve motor and sensory nerve conduction velocity, median nerve motor and sensory nerve conduction velocity, Dengzhanxixin Injection combined with conventional drugs is superior to simple conventional treatment. There was no statistical difference between the two groups in the improvement of ulnar nerve conduction velocity. Conclusion Dengzhan Xixin Injection combined with conventional drug is superior to conventional drug therapy in improving the clinical outcomes of diabetic peripheral neuropathy.

北京市中醫(yī)管理局資助項目（JJ2016-15）；北京市醫(yī)院管理局重點醫(yī)學(xué)專業(yè)發(fā)展計劃建設(shè)項目（ZYLX201812）