目的 探討醒腦靜乳劑聯(lián)合納洛酮對腦缺血-再灌注損傷后神經(jīng)細胞凋亡的影響。方法 采用回顧性研究方法，2013年8月-2018年2月選擇在安陽市第二人民醫(yī)院神經(jīng)內(nèi)科進行診治的對腦缺血-再灌注損傷患者120例，根據(jù)治療方法的不同分為觀察組與對照組各60例，對照組給予納洛酮治療，觀察組給予醒腦靜乳劑聯(lián)合納洛酮治療，兩組都以14 d為1個療程，治療觀察2個療程。比較兩組臨床療效、神經(jīng)功能缺損評分、炎癥因子及神經(jīng)組織細胞凋亡情況。結(jié)果 治療后觀察組與對照組的總有效率分別為98.33%和88.33%，觀察組顯著高于對照組（P<0.05）。治療后，兩組的神經(jīng)功能缺損評分都顯著低于治療前（P<0.05），且觀察組顯著低于對照組（P<0.05）。治療后，兩組的血清白介素（IL）-6與IL-10含量顯著低于治療前（P<0.05），且觀察組顯著低于對照組（P<0.05）。治療后，觀察組與對照組的神經(jīng)細胞凋亡率分別為（3.22±1.29）%和（12.10±2.19）%，觀察組顯著少于對照組（P<0.05）。結(jié)論 醒腦靜乳劑聯(lián)合納洛酮治療腦缺血-再灌注損傷能抑制神經(jīng)細胞凋亡，緩解神經(jīng)缺損功能，抑制炎癥抑制的釋放，從而提高治療效果。

Objective To explore the effects of Xingnaojing emulsion combined with naloxone on neuronal apoptosis for cerebral ischemia-reperfusion injury. Methods From August 2013 to February 2018, 120 patients with cerebral ischemia reperfusion injury were selected in the neurology department of our hospital and were divided into the experimental group and the control group of 60 patients in each groups. The control group were given the naloxone treatment, the experimental group were given emulsion combined with naloxone treatment. The two groups were treated with 14 d for 1 courses, and two courses of treatment were observed. Results After treatment, the total effective rates of the experimental group and the control group were 98.33% and 88.33%, respectively, and the experimental group were higher than that of the control group (P<0.05). The neurological deficit scores of the experimental group and the control group after treatment were significantly lower than those before treatment (P<0.05), and the experimental group were significantly lower than that of the control group (P<0.05). The serum IL-6 and IL-10 levels in the experimental group and the control group after treatment were significantly lower than those before treatment, and the observation group were significantly lower than that in the control group (P<0.05). After treatment, the apoptosis rates of the experimental group and the control group were (3.22 ±1.29)% and (12.10 ±2.19)% respectively, and the observation group were significantly less than that of the control group (t=15.249, P=0.000). Conclusion Xingnaojing emulsion combined naloxone in the treatment of cerebral ischemia-reperfusion injury can inhibit the apoptosis of nerve cells, relieve the function of nerve defect, inhibit the release of inflammatory inhibition, and improve the therapeutic effect.