目的 探討益生菌聯(lián)合血必凈注射液對(duì)急性胰腺炎患者的療效及對(duì)降鈣素原（PCT）、C反應(yīng)蛋白（CRP）及D-二聚體的影響。方法 選取2015年12月-2017年12月鄭州大學(xué)附屬鄭州中心醫(yī)院收治的急性胰腺炎患者185例，隨機(jī)將患者分為兩組，對(duì)照組在常規(guī)治療的基礎(chǔ)上給予血必凈注射液，觀察組在對(duì)照組的基礎(chǔ)上給予雙歧桿菌乳桿菌三聯(lián)活菌片，連續(xù)治療7 d。比較兩組治療總有效率、臨床癥狀和體征緩解時(shí)間及治療前后PCT、CRP及血漿D-二聚體水平。結(jié)果 觀察組總有效率為92.47%，顯著高于對(duì)照組的81.52%（P<0.05）；觀察組患者的腹痛腹脹緩解時(shí)間、惡心嘔吐消失時(shí)間、腸鳴音恢復(fù)時(shí)間和血尿淀粉酶恢復(fù)時(shí)間均顯著短于對(duì)照組（P<0.05）。治療后，兩組PCT、CRP及血漿D-二聚體水平均較治療前顯著下降（P<0.05），且觀察組顯著低于對(duì)照組（P<0.05）。結(jié)論 雙歧桿菌乳桿菌三聯(lián)活菌片聯(lián)合血必凈注射液可顯著縮短急性胰腺炎患者臨床癥狀及體征緩解時(shí)間，降低炎癥反應(yīng)，改善高凝狀態(tài)，提高治療的有效率。

Objective To investigate the effect of probiotics combined with Xuebijing Injection on PCT,CRP and D-D in patients with acute pancreatitis.Methods 185 cases of patients with acute pancreatitis were selected in our hospital from December 2015 to December 2017,and were divided into two groups.The control group were gave Xuebijing Injection on the basis of conventional treatment,the observation group were gave Bifidobacterium lactobacillus triple live bacteria tablet on the basis of the control group.Clinical therapeutic effects,remission time of clinical symptoms and signs,the levels of PCT,CRP and D-D before and after the treatment were compare between two groups.Results After treatment,the total effective rate of the observation group was significantly higher than that of the control group (P<0.05).The time of abdominal pain and distension relieving,disappearance of nausea and vomiting,recovery of intestinal singing and hematuria amylase in the observation group were significantly shorter than those in the control group (P<0.05).There were no statistically significant differences in PCT,CRP and D-D levels between the two groups before treatment.After treatment,the above indicators were significantly decreased in both groups,and the observation group was significantly lower than the control group (P<0.05).Conclusion Bifidobacterium lactobacillus triple live bacillus tablets combined with Xuebijing Injection can significantly shorten the relief time of clinical symptoms and signs in patients with acute pancreatitis,reduce the inflammatory reaction,improve the hypercoagulation state,and improve the efficiency of treatment.

河南省科技攻關(guān)計(jì)劃項(xiàng)目（2018020772）