目的 探討牛黃寧宮片聯(lián)合齊拉西酮與奧氮平在精神分裂癥治療中的臨床療效。方法 選取2016年1月-2017年12月南陽(yáng)市精神病醫(yī)院71例精神分裂癥患者為研究對(duì)象，根據(jù)硬幣投擲法將受試者分為對(duì)照組35例和觀察組36例，對(duì)照組給予齊拉西酮聯(lián)合奧氮平治療，觀察組患者在對(duì)照組的基礎(chǔ)上聯(lián)合牛黃寧宮片治療，兩組均持續(xù)治療6周。比較兩組患者的臨床療效、治療前后陽(yáng)性和陰性綜合征量表（PANSS）評(píng)分、臨床總體印象-嚴(yán)重度量表（CGI-S）評(píng)分、患者的社會(huì)功能變化及不良反應(yīng)發(fā)生率。結(jié)果 觀察組患者治療總有效率為88.89%，對(duì)照組患者治療總有效率為62.86%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療前兩組患者的PANSS評(píng)分、CGI-S評(píng)分及患者的社會(huì)功能比較無(wú)統(tǒng)計(jì)學(xué)差異，治療后兩組患者CGI-SI及PANSS評(píng)分較治療前均顯著降低（P<0.05），社會(huì)功能各指標(biāo)評(píng)分較治療前均顯著升高（P<0.05）；且觀察組優(yōu)于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組不良反應(yīng)發(fā)生率為11.11%，對(duì)照組不良反應(yīng)發(fā)生率為42.86%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 牛黃寧宮片聯(lián)合齊拉西酮與奧氮平可有效改善患者的臨床癥狀，提高治療效果及患者的社會(huì)功能，減少不良反應(yīng)，在精神分裂癥治療中具有重要臨床意義。

Objective To explore clinical effect of Niuhuang Ninggong Table combined with ziprasidone and olanzapine in the treatment of schizophrenia.Methods 71 patients with schizophrenia were selected as the subjects from January 2016 to December 2017. According to the coin throwing method, all patients were divided into control group of 35 cases and study group of 36 cases. The control group were treated with ziprasidone and olanzapine, the experimental group on the basis of this combination of Niuhuang Ninggong Table. The clinical effect, the PANSS score and CGI-S score, the changes of social function before and after treatment and the incidence of adverse reactions were compared between the two groups. Results The total effective rate in the experimental group were significant higher than in the control group (88.89% vs 62.86%) (P<0.05), there were no significant differences in the PANSS score, CGI-S score and social function between the control group before treatment. After treatment, the PANSS score and CGI-S score of the study group were significantly lower than before treatment, the social function significantly improve than before treatment, and the experimental group were obviously better than the control group, and there was significant difference (P<0.05). The incidence of adverse reactions in the experimental group were significant lower than in the control group (11.11% vs 42.86%) (P<0.05).Conclusion s Niuhuang Ninggong Table combined with ziprasidone and olanzapine in the treatment of schizophrenia can effectively improve clinical symptoms, increase social function and treatment efficacy, and reduce adverse reactions, has improtant value.