目的 觀察纈沙坦氫氯噻嗪對高血壓患者的療效。方法 前瞻性入組西安北車醫(yī)院收治的180例高血壓患者，經(jīng)過2周藥物洗脫期后，隨機分為觀察組（n=90）和對照組（n=90）。對照組給予纈沙坦片，1片/次，1次/d。觀察組給予纈沙坦氫氯噻嗪片，1片/次，1次/d。兩組均治療8周。比較兩組患者治療前后的坐位收縮壓和舒張壓，比較治療后兩組患者的天門冬氨酸氨基轉(zhuǎn)移酶（AST）、丙氨酸氨基轉(zhuǎn)移酶（ALT）和肌酐，并記錄治療期間的不良事件發(fā)生率。結(jié)果 治療前，兩組患者坐位收縮壓和舒張壓無顯著性差異。治療8周后，兩組患者坐位收縮壓和舒張壓均下降，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組患者的坐位收縮壓和舒張壓顯著低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組患者治療前后AST、ALT、肌酐等指標(biāo)均無統(tǒng)計學(xué)差異。觀察組患者不良反應(yīng)發(fā)生率為8.9%，顯著低于對照組的27.8%，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 纈沙坦氫氯噻嗪有較好的降壓作用，且不良事件少。

Objective To evaluate the efficacy of Valsartan and Amlodipine Tablet in hypertension patients.Methods After 2 weeks wash out, 180 patients with hypertension were enrolled, and were randomly divided into the observation group (n=90) and control group (n=90). The control group was given Valsartan Tablets, 1 tablets per time, 1 times per day. The observation group was given Valsartan and Hydrochlorothiazid Tablets, 1 tablets per time, 1 times per day. The two groups were treated for 8 weeks. The sitting systolic/diastolic blood pressure between the two groups before and after treatment were compared. Then aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine were compared between the two groups after treatment, and the incidence of adverse events during the treatment was recorded. Results Before treatment, there was no significant difference in systolic blood pressure and diastolic blood pressure between the two groups. After 8 weeks of treatment, the sitting systolic and diastolic blood pressure of the two groups decreased, and there was a significant difference between the two groups before and after treatment (P<0.05), and the sitting systolic and diastolic blood pressure of the observation group was significantly lower than that of the control group (P<0.05). There was no significant difference in AST, ALT and creatinine between the two groups before and after treatment. The incidence of adverse reactions in the observation group was 8.9%, which was significantly lower than that in the control group (27.8%) (P<0.05).Conclusions The combination therapy with Valsartan and Amlodipine Tablet have a good antihypertensive effect, and fewer adverse events.