阿爾茨海默?。ˋD）是最常見的神經(jīng)退行性疾病之一，且目前尚無徹底治愈方法，常規(guī)的藥物治療可暫時緩解或穩(wěn)定癥狀，但無法阻止疾病的長期進(jìn)展。中藥治療AD療效顯著，且與西醫(yī)療法聯(lián)用可起到增效減毒的功效。因此，從中藥中尋找有效的抗AD藥物已經(jīng)成為熱門的研究領(lǐng)域。中藥的多組分特性使得其發(fā)揮藥理作用具有多途徑、多靶點(diǎn)、多通路的優(yōu)勢，總結(jié)目前研究發(fā)現(xiàn)的具有防治AD作用的中藥（黃芪、人參、淫羊藿、巴戟天、當(dāng)歸、銀杏葉等）成分（組分）改善AD的作用靶點(diǎn)、分子信號通路及復(fù)雜的調(diào)控網(wǎng)絡(luò)，闡明中藥成分（組分）發(fā)揮治療AD作用的機(jī)制，為AD的臨床治療及從中藥成分（組分）中發(fā)現(xiàn)新的AD治療藥物提供思路和參考。

Alzheimer’s disease（AD） is one of the most common neurodegenerative diseases, and there is no complete cure yet. Conventional drug therapy can temporarily alleviate or stabilize symptoms, but cannot prevent the long-term progression of the disease. Traditional Chinese medicine has significant therapeutic effects on AD, and when combined with western medicine therapy, it can enhance efficacy and reduce toxicity. Therefore, finding effective anti ad drugs from traditional Chinese medicine has become a hot research field. The multi-component characteristics of traditional Chinese medicine make it have the advantages of multi-channel, multi-target and multi-channel to play its pharmacological role. This paper summarizes the components（components） of traditional Chinese medicine（Astragali Radix, Ginseng Radix et Rhizoma, Epimedii Folium, Morindae Officinalis Radix, Angelicae Sinensis Radix, Ginkgo Folium, etc.） with the effect of preventing and treating AD, which can improve the action targets, molecular signaling pathways and complex regulatory networks of AD, and clarify the mechanism of traditional Chinese medicine components in the treatment of AD, so as to provide ideas and references for the clinical treatment of AD and the discovery of new ad therapeutic drugs from traditional Chinese medicine components.

R285.5

黑龍江省自然科學(xué)基金資助項目(LH2023H073)