皮膚穿透肽（SPP）是一類能夠促進藥物或活性成分通過皮膚屏障的肽類分子。SPP具有良好的生物相容性和安全性，可用于輸送各種類型的藥物或活性成分，包括小分子藥物、蛋白質(zhì)和核酸。這些特點使得SPP在醫(yī)藥和化妝品領域中具有廣泛的應用前景。目前國內(nèi)外科研人員對于SPP的結構、機制、設計和應用進行了廣泛的探索和實驗。按來源分類，SPP可分為3類：蛋白質(zhì)來源的SPP、基因重組來源的SPP和人工設計合成的SPP；其促滲機制可以從作用于角質(zhì)層和作用于皮膚附屬器這2個方面來闡述；其主要的應用方式包括4種：SPP與藥物的物理混合、SPP與藥物形成共價連接、SPP與蛋白類藥物形成融合蛋白、SPP修飾藥物載體，綜述 SPP不同來源 SPP種類、不同 SPP的促滲機制及應用方式，分析其研究與應用中存在的問題，以期為SPP的開發(fā)和創(chuàng)新提供有價值的參考。

Skin-penetrating peptides (SPP) are a type of peptide molecules that can promote the passage of drugs or active ingredients through the skin barrier. SPP has good biocompatibility and safety, and can be used to deliver various types of drugs or active ingredients, including small molecule drugs, proteins and nucleic acids. These characteristics make SPP have broad application prospects in the fields of medicine and cosmetics. Global researchers have conducted extensive exploration and experiments on the structure, mechanism, design and application of SPP. According to the source, SPP can be classified into three categories: protein-derived SPP, recombinant-derived SPP, and artificially designed and synthesized SPP. Its osmotic mechanism can be elaborated from the aspects of its action on the stratum corneum and its action on the skin appendages, and its main application modes include four types: the physical mixing of SPP and drugs, the formation of covalent linkage between SPP and drugs, the formation of fusion between SPP and protein drugs, and the modification of drug carriers by SPP. The main application modes include four types: physical mixing of SPP and drug, covalent linkage of SPP and drug, fusion of SPP and protein drug, and modification of drug carrier by SPP. We will review the types of SPP from different sources of SPP, the mechanism of promotion of infiltration and application modes of different SPPs, and analyze the problems in their research and application, in order to provide valuable references for the development and innovation of SPP.

R945

深圳技術大學新引進高端人才財政補助科研啟動項目（20200215）