目的 總結(jié)天津地區(qū)境外輸入新型冠狀病毒肺炎（COVID-19）病例中醫(yī)湯劑用藥規(guī)律。方法 回顧性選擇2019年12月—2021年5月天津市海河醫(yī)院收治的境外輸入輕型/普通型COVID-19病例，納入中醫(yī)治療有效的病例為研究對象，建立數(shù)據(jù)庫，錄入患者一般資料、臨床癥狀、中藥處方等數(shù)據(jù)，采用數(shù)據(jù)挖掘方法，歸納中藥使用頻次、高頻中藥藥對和藥簇、中醫(yī)聚類處方。結(jié)果 納入患者224例，中藥湯劑處方224首，涉及中藥148味，高頻中藥35味，藥性溫（1 730次，41.79%）、藥味苦（2 433次，39.23%）、入肺經(jīng)（3 094次，30.19%）、清熱藥（990次，23.93%）和化痰止咳平喘藥（807次，19.51%）使用頻次最多；茯苓＋陳皮、半夏＋陳皮和虎杖＋陳皮是常見的藥對；茯苓＋陳皮+虎杖和半夏＋陳皮+虎杖是常見的角藥；得出6組中藥藥簇和6類中醫(yī)聚類處方。結(jié)論 初步歸納出6類藥簇和6個(gè)聚類處方，用于COVID-19各型各證的選方和加減，為中醫(yī)治療COVID-19提供臨床選方用藥參考。

Objective To summarize the herbal prescription rule of traditional Chinese medicine in treatment of imported COVID-19 cases in Tianjin. Methods From December 2019 to May 2021, the light/ordinary COVID-19 cases imported from abroad were selected as the research objects, and the cases that were effectively treated by traditional Chinese medicine were included. A database was established, and data such as patients' general information, clinical symptoms and prescriptions of traditional Chinese medicine were entered. By using data mining methods, the frequency of use of traditional Chinese medicine, high-frequency pairs and clusters of traditional Chinese medicine and prescriptions of traditional Chinese medicine were summarized. Results Totally 224 patients were included, and there were 224 treatment prescriptions, involving 148 kinds of Chinese materia medica, 35 kinds of highfrequency Chinese materia medica. The Chinese materia medica were mild in nature (1 730 times, 41.79%), bitter in taste (2 433 times, 39.23%), entering the lung meridian (3 094 times, 30.19%), clearing heat (990 times, 23.93%) and resolving phlegm, relieving cough and relieving asthma (807 times, 19.51%). Poria cocos+Pericarpium Citri Tangerinae, Pinellia ternata+Pericarpium Citri Tangerinae and Polygonum Cuspidatum+Pericarpium Citri Tangerinae are common drug pairs. Poria cocos+Pericarpium Citri Tangerinae+Polygonum Cuspidatum and Pinellia ternata+Pericarpium Citri Tangerinae+Polygonum Cuspidatum are common horn drugs. Six groups of traditional Chinese medicine clusters and six kinds of traditional Chinese medicine cluster prescriptions were obtained. Conclusion Six cluster prescriptions were preliminarily summarized, which were used for the selection, addition and subtraction of each syndrome of COVID-19, and provided clinical reference for the treatment of COVID-19 by traditional Chinese medicine.

R974

天津市衛(wèi)生健康委、天津市中醫(yī)藥管理局中醫(yī)、中西醫(yī)結(jié)合科研課題（2021098）