動(dòng)物實(shí)驗(yàn)證實(shí)厚樸及其有效成分（厚樸酚、和厚樸酚等）具有防治阿爾茨海默病和帕金森病的藥理作用。它們最主要的作用機(jī)制是抗氧化和抗炎作用：通過直接清除自由基和提高機(jī)體的核因子紅系2-相關(guān)因子-2（Nrf2）抗氧化信號通路和抗氧化酶活性間接清除自由基的方式抑制活性氧生成；通過激活去乙酰化酶（SIRT），阻滯磷脂酰肌醇-3激酶（PI3K）/蛋白激酶-B（Akt），細(xì)胞外信號調(diào)節(jié)蛋白激酶（ERK）/絲裂原活化蛋白激酶（MAPK）和Toll樣受體-2（TLR2）/MAPK/核因子-κB（NF-κB）信號通路和促進(jìn)線粒體自噬，抑制炎性細(xì)胞因子表達(dá)，保護(hù)腦神經(jīng)（包括海馬、黑質(zhì)和紋狀體等），表現(xiàn)出防治阿爾茨海默病和帕金森病的作用。

In animal experiments Magnoliae Officinalis Cortex and its active components (magnolol, honokiol) have the pharmacologic effects in prevention and treatment for Alzheimer`s disease and Parkinson`s disease. Their basic mechanisms are antioxidation and anti-inflammation: by scavenging direct free radial and eliminating indirect free radial through up-regulating Nrf2 anti-oxidative signaling pathway and activity of antioxidases to decrease produce of ROS, and by activation of SIRT, blocking these signaling pathways of PI3K/Akt, ERK/MAPK and TLR2/MAPK/NF-κB, and promoting mitophagy to inhibit the expression of inflammatory cytokines, and to produce neuroprotective effect in brain (including hippocampus, nigra and striatum), so show the effect to prevent and treat for Alzheimer's disease and Parkinson's disease.

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