中醫(yī)藥在新型冠狀病毒疫情防控方面起到重要作用，讓世界對中醫(yī)藥有了新的認(rèn)識。但是，由于中醫(yī)藥的作用機(jī)制、藥效物質(zhì)、分子靶標(biāo)等不明確，限制其廣泛應(yīng)用。代謝組學(xué)的出現(xiàn)為這一系列問題的解決提供切實(shí)可行的技術(shù)方法。通過對近2年有關(guān)文獻(xiàn)的查閱，闡述代謝組學(xué)在證候或疾病的表征以及中藥的藥效評價(jià)、藥效物質(zhì)、作用機(jī)制、質(zhì)量標(biāo)志物等方面的研究進(jìn)展，以期為代謝組學(xué)在中醫(yī)藥作用機(jī)制、藥效物質(zhì)等方面的深入研究提供參考。

Traditional Chinese medicine (TCM) plays an important role in the prevention and control of COVID-19, which gives the world a new understanding of TCM. Due to the unclear mechanism of action, effective substances and molecular targets, its wide application is limited. The emergence of metabolomics provides a feasible technical method for solving this series of problems. Through the review of relevant literature in the past two years, this paper expounds the research progress of metabolomics in the characterization of syndromes / diseases, the evaluation of efficacy, effective substances, mechanism of action, quality markers and other aspects of TCM, in order to provide reference for the research of metabolomics in TCM.

R285.5

國家自然科學(xué)基金自助項(xiàng)目（81973745，82104733）