威靈仙是我國常用的、多基原大宗中藥材，具有抗炎鎮(zhèn)痛、保護軟骨、保肝、抗癌、抗菌抑菌、降糖等多種作用。其主要通過抑制炎性因子、抑制信號通路等發(fā)揮抗炎鎮(zhèn)痛作用，通過調(diào)節(jié)相關(guān)因子、相關(guān)通路表達而抑制細胞凋亡等發(fā)揮保護軟骨的作用，通過調(diào)節(jié)肝臟免疫、降低內(nèi)毒素水平等發(fā)揮保肝作用，通過調(diào)節(jié)相關(guān)基因表達發(fā)揮抗癌作用，通過破壞細胞膜發(fā)揮抗菌作用，通過調(diào)控信號通路、平衡胰島細胞數(shù)量發(fā)揮降糖作用。對近年來威靈仙的藥理作用及作用機制進行梳理總結(jié)，以期為其進一步開發(fā)利用提供參考。

Clematidis Radix et Rhizoma is a commonly used, multi-based, bulk Chinese medicinal material in my country. Studies have shown that it has anti-inflammatory and analgesic, cartilage protection, liver protection, anticancer, antibacterial, antibacterial, hypoglycemic and other effects. After reviewing the literature, it was found that it mainly exerts anti-inflammatory and analgesic effects by inhibiting inflammatory factors and signaling pathways, and protects cartilage by regulating the expression of related factors and related pathways and inhibiting cell apoptosis. Endotoxin levels play a role in liver protection, anti-cancer effects by regulating the expression of related genes, antibacterial effects by destroying cell membranes, and hypoglycemic effects by regulating signaling pathways and balancing the number of islet cells. This article summarizes the pharmacological effects and mechanism of Clematidis Radix et Rhizoma in recent years, in order to provide a reference for the further development and utilization of Clematidis Radix et Rhizoma.

R285.5

山東省新舊動能轉(zhuǎn)換重大產(chǎn)業(yè)攻關(guān)項目（魯動能辦[2021]23號）；山東省重點研發(fā)計劃（重大科技創(chuàng)新工程）項目（2020CXGC010505，2021CXGC010508）