目的 基于國(guó)內(nèi)外藥品價(jià)值評(píng)估的研究現(xiàn)狀、熱點(diǎn)及發(fā)展趨勢(shì)分析，提出我國(guó)藥品價(jià)值評(píng)估研究的攻關(guān)方向與策略建議。方法 檢索中國(guó)期刊全文數(shù)據(jù)庫(kù)（CNKI）自建庫(kù)至2021年9月和WebofScience核心數(shù)據(jù)庫(kù)1993年至2021年10月發(fā)表的與藥品價(jià)值評(píng)估相關(guān)文獻(xiàn)，采用CiteSpace可視化軟件從作者及機(jī)構(gòu)、關(guān)鍵詞及文獻(xiàn)共被引等方面進(jìn)行分析，構(gòu)建藥品價(jià)值評(píng)估知識(shí)圖譜。結(jié)果 英文發(fā)文量2004年后猛增，發(fā)文量最高的作者為Yot Teerawattananon，而中文發(fā)文量在2015年后激增，發(fā)文量最高的作者為翟所迪；在作者與機(jī)構(gòu)合作方面，國(guó)內(nèi)各機(jī)構(gòu)團(tuán)隊(duì)之間合作較緊密，國(guó)外主要集中于機(jī)構(gòu)團(tuán)隊(duì)內(nèi)部；在研究熱點(diǎn)上，國(guó)內(nèi)研究集中在中成藥注射液、化療藥、單抗藥等藥品的有效性、安全性和經(jīng)濟(jì)性評(píng)價(jià)，而國(guó)外機(jī)構(gòu)更加關(guān)注價(jià)值評(píng)估方法學(xué)的研究與評(píng)估變量的選擇。結(jié)論 國(guó)內(nèi)藥品價(jià)值評(píng)估研究基本上處于跟隨式研究，評(píng)估的規(guī)范性、透明性均需加強(qiáng)。未來(lái)應(yīng)從藥品價(jià)值評(píng)估工作規(guī)范性的加強(qiáng)，評(píng)估方法體系以及中成藥特有的價(jià)值評(píng)估框架的構(gòu)建等方面著力推進(jìn)我國(guó)藥品價(jià)值評(píng)估工作。

Objective To put forward the research direction and suggestions of Chinese drug value assessment in the future based on the analysis of the research status, hot spots and development trend of the drug value assessment in China and abroad.Methods The literatures related to value assessment published in CNKI from the establishment of the database to September, 2021 and Web of Science core database from 1993 to Octorber, 2021 were retrieved, and the Cite Space visualization software was used to construct the knowledge map of drug value assessment based on the analysis with the authors and institutions, keywords and references cocitation.Results The number of articles published in English increased rapidly after 2004, and the author with the highest number of articles was Yot Teerawattananon.However, the number of articles published in Chinese increased rapidly only after 2015, and the the author with the highest number of articles was Suodi Zhai.In terms of cooperation between authors and institutions, the domestic research teams had closer cooperation than the abroad.While the cooperation in foreign countries was mainly concentrated within the institutional teams.As for the hot research topics, the domestic research focused on the efficacy, safety and economic evaluation of Chinese medicine injection, chemotherapy drugs, monoclonal antibodies and other drugs, while foreign institutions paid more attention to the research on the assessment methodology and the selection of evaluation variables.Conclusion The research on drug value assessment in China is basically follow-up research, and the standardization and transparency of evaluation need to be strengthened.In the future, the standardization of drug value assessment should be strengthened, the evaluation method system and the unique evaluation framework of Chinese patent medicine should be constructed to promote drug value evaluation research.

R9

國(guó)家食品藥品監(jiān)督管理總局政策研究課題（G20150I）