目的 系統(tǒng)評(píng)價(jià)小兒豉翹清熱顆粒聯(lián)合阿奇霉素治療兒童肺炎支原體肺炎的臨床療效及安全性。方法 計(jì)算機(jī)檢索中文學(xué)術(shù)期刊全文數(shù)據(jù)庫(kù)（CNKI）、維普中文期刊全文數(shù)據(jù)庫(kù)（VIP）、萬(wàn)方數(shù)據(jù)庫(kù)（Wanfang Data）、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)（CBM）、Cochrane Library、PubMed和Web of Science等中英文數(shù)據(jù)庫(kù)，收集小兒豉翹清熱顆粒聯(lián)合阿奇霉素治療兒童肺炎支原體肺炎的臨床隨機(jī)對(duì)照試驗(yàn)（RCT），時(shí)限為建庫(kù)起至2021年6月15日，使用RevMan 5.4軟件進(jìn)行Meta分析。結(jié)果 共納入9篇RCTs、包括1 072例患兒。Meta分析結(jié)果顯示：小兒豉翹清熱顆粒聯(lián)合阿奇霉素組較對(duì)照組能提高總有效率［RR=1.16，95% CI（1.05，1.27），P=0.003］、縮短咳嗽消失時(shí)間［MD=-2.54，95% CI（-3.44，-1.46），P<0.000 01］、縮短肺部啰音消失時(shí)間［MD=-2.55，95% CI（-4.39，-0.70），P=0.007］、退熱時(shí)間［MD=-2.08，95% CI（-2.84，-1.31），P<0.000 01］、降低白細(xì)胞介素-6水平［MD=-7.88，95% CI（-12.33，-3.43），P=0.000 5］、降低不良反應(yīng)率［RR= 0.44，95% CI（0.28，0.68），P=0.000 2］，且差異均有統(tǒng)計(jì)學(xué)意義。結(jié)論 小兒豉翹清熱顆粒聯(lián)合阿奇霉素治療兒童肺炎支原體肺炎的療效優(yōu)于單用阿奇霉素，且更安全。

Objective To systematically evaluate the clinical efficacy and safety of Xiaoer Chiqiao Qingre Granules combined with azithromycin in the treatment of children with Mycoplasma pneumoniae pneumonia (MPP). Methods A computer search of Chinese academic Journal full-text Database (CNKI), VIP Chinese Journal full-text Database (VIP), Wanfang Database (Wanfang Data), China Biomedical Literature Database (CBM), The Cochrane Library, PubMed, and Web of Science, in order to collect the randomized controlled trials (RCT) of Xiaoer Chiqiao Qingre Granules combined with azithromycin in the treatment of children with MPP. The retrieval time is from the establishment of the database to June 15, 2021. Statistical analysis was carried out by using RevMan 5.3 software. Results A total of 9 RCTs including 1 072 children were included. Meta-analysis results show that as compared with control group, Xiaoer Chiqiao Qingre Granules combined with azithromycin group is more improving clinical efficiency rate [RR=1.16, 95%CI (1.05, 1.27), P=0.003], shorten cough disappearance time [MD=-2.55, 95%CI (-3.44,-1.46), P<0.000 01], shorten lung rale disappearance time [MD=-2.55, 95%CI (-4.39,-0.70), P=0.007], shorten fever disappearance time [MD=-2.08, 95%CI (-2.84,-1.31), P<0.000 1], debase IL-6 value after treatment [MD=-7.88, 95%CI (-12.33, -3.43), P=0.0005], debase adverse reaction rate [RR=0.44, 95%CI (0.28, 0.68), P=0.0002], the differences were statistically significant. Conclusion Xiaoer Chiqiao Qingre Granules combined with azithromycin in the treatment of children with MPP is more effective than azithromycin alone and is safer.

R287.5

青年科學(xué)基金資助項(xiàng)目（82004422）