肌酐作為一種高效的腎功能生物標(biāo)志物，已在臨床上被廣泛用于腎病的診斷以及對腎臟相關(guān)藥物的評價。肌酐亦在其他系統(tǒng)疾病診斷、尿樣中待檢測物質(zhì)的校準(zhǔn)以及機能評定方面有一定作用。對肌酐的臨床應(yīng)用進行綜述，并著重介紹了肌酐在腎病診斷，以及對腎臟相關(guān)藥物的藥效和不良反應(yīng)評價的應(yīng)用，并展望了肌酐在臨床診斷、藥物評價等方面的應(yīng)用前景。

As a highly effective biomarker of kidney function, creatinine has been used clinically in the diagnosis of kidney disease and the evaluation of kidney-related drugs. It is also useful in the diagnosis of other systemic diseases, the calibration of substances to be tested in urine samples, and the assessment of function. This article reviews the clinical applications of creatinine and highlights the use of creatinine in the diagnosis of kidney disease and in the evaluation of the efficacy and adverse effects of kidneyrelated drugs, and concludes that creatinine has a promising future in clinical diagnosis and drug evaluation.

R965.3

國家自然科學(xué)基金重點資助項目（81830109）