目的 探討注射用燈盞花素聯(lián)合丁苯酞氯化鈉注射液治療急性腦梗死的臨床療效。方法 選取2018年1月—2020年12月滁州市中西醫(yī)結合醫(yī)院收治的80例急性腦梗死患者作為研究對象，按照治療方法將患者分為對照組和觀察組，每組各40例。對照組靜脈滴注丁苯酞氯化鈉注射液，100 mL/次，2次/d。觀察組在對照組基礎上靜脈滴注注射用燈盞花素，20 mg加入250 mL生理鹽水，1次/d。兩組均連續(xù)治療14 d。觀察兩組患者的臨床療效，比較兩組治療前后的NIHSS評分、血清淀粉樣蛋白A（SAA）、同型半胱氨酸（Hcy）、人趨化素（Chemerin）的水平，以及患者缺血低灌注區(qū)面積。結果 治療后，觀察組的總有效率為95.00%，明顯高于對照組的80.00%，差異有統(tǒng)計學意義（P<0.05）。治療后，兩組NIHSS評分明顯降低（P<0.05），且觀察組NIHSS評分顯著低于對照組（P<0.05）。治療后，兩組的SAA、Hcy、Chemerin水平均顯著降低（P<0.05）；治療后，觀察組的SAA、Hcy、Chemerin顯著低于對照組，差異有統(tǒng)計學意義（P<0.05）。治療后，兩組的缺血低灌注區(qū)面積顯著縮?。?i>P<0.05），且觀察組顯著低于對照組（P<0.05）。結論 注射用燈盞花素聯(lián)合丁苯酞氯化鈉注射液治療急性腦梗死的療效顯著，可改善患者神經(jīng)功能，縮小缺血低灌注區(qū)面積，降低SAA、Hcy、Chemerin的水平，具有良好的安全性。

Objective To investigate the clinical efficacy of Breviscapine for injection combined with Butylphthalide and Sodium Chloride Injection in treatment of acute cerebral infarction. Methods Eighty cases of acute cerebral infarction patients treated in Chuzhou Integrated Traditional Chinese and Western Medicine Hospital from January 2018 to December 2020 were selected as the research object, and the patients were divided into control group and observation group according to the treatment method, with 40 cases in each group. Patients in the control group was intravenously injected with Butylphthalide and Sodium Chloride Injection, 100 mL time, twice daily. Patients in the observation group were administered with Breviscapine for injection on the basis of control group, 20 mg added with 250 mL normal saline, once daily. Both groups were treated continuously for 14 d. Clinical efficacy of two groups was observed, and NIHSS scores, serum SAA, Hcy, Chemerin levels, and the area of ischemia and hypoperfusion area of two groups were compared before and after treatment. Results After treatment, the total effective rate of the observation group was 95.00%, significantly higher than 80.00% of the control group, and the difference was statistically significant (P < 0.05). After treatment, the NIHSS scores in two groups were significantly decreased (P < 0.05), and the NIHSS scores in the observation group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of SAA, Hcy and Chemerin in two groups were significantly decreased (P < 0.05). After treatment, SAA, Hcy and Chemerin in the observation group were significantly lower than those in the control group, with statistical significance (P < 0.05). After treatment, the area of ischemic hypoperfusion area in both groups was significantly reduced (P < 0.05), and the observation group was significantly lower than the control group (P < 0.05). Conclusion Breviscapine for injection combined with Butylphthalide and Sodium Chloride Injection has significant efficacy in treatment of acute cerebral infarction, which can improve the neurological function of patients, reduce the area of ischemia and low perfusion area, and reduce the levels of SAA, Hcy, and Chemerin, showing good safety.

R971

國家自然科學基金資助項目（82060894）