目的 觀察注射用丹參多酚酸聯(lián)合阿司匹林和阿托伐他汀治療大面積腦梗死的神經(jīng)功能改善情況及梗死體積的變化。方法 選取2016年4月-2019年9月駐馬店市中心醫(yī)院收治的大面積腦梗死患者108例為研究對(duì)象。隨機(jī)將患者分為對(duì)照組（50例）和觀察組（58例）。對(duì)照組給予阿司匹林腸溶片，100 mg/d；阿托伐他汀鈣片，40 mg/d。觀察組在對(duì)照組治療的基礎(chǔ)上靜脈滴注注射用丹參多酚酸，0.13 g/d。兩組患者均輸液治療2周。觀察并比較兩組患者的美國(guó)國(guó)立衛(wèi)生院卒中量表（NIHSS）評(píng)分、Barthel指數(shù)評(píng)分及腦梗死體積。結(jié)果 治療后1個(gè)月及3個(gè)月時(shí)，對(duì)照組NIHSS評(píng)分顯著降低；治療后2周、1個(gè)月及3個(gè)月，觀察組NIHSS評(píng)分顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.01）。治療后2周、1個(gè)月及3個(gè)月，觀察組NIHSS評(píng)分顯著低于同期對(duì)照組（P<0.01）。治療1個(gè)月及3個(gè)月時(shí)，兩組Barthel評(píng)分均顯著升高，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.01）；且觀察組Barthel評(píng)分顯著高于同期對(duì)照組（P<0.01）。對(duì)照組在治療3個(gè)月時(shí)腦梗死體積較治療前顯著降低，觀察組在治療1個(gè)月及3月時(shí)腦梗死體積顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.01）。治療1個(gè)月時(shí)，觀察組腦梗死體積顯著低于對(duì)照組，兩組間比較差異有統(tǒng)計(jì)學(xué)意義（P<0.01）。結(jié)論 注射用丹參多酚酸聯(lián)合阿司匹林和阿托伐他汀治療大面積腦梗死患者可降低患者病死率，對(duì)患者生活質(zhì)量、神經(jīng)功能恢復(fù)及梗死體積均有一定的影響。

Objective To observe the improvement of nerve function and the change of infarct volume in treatment of massive cerebral infarction with Salvianolic Acid for Injection. Methods A total of 108 patients with massive cerebral infarction admitted to Zhumadian Central Hospital from April 2016 to September 2019 were selected as the research objects. Patients were randomly divided into control group (50 cases) and observation group (58 cases). Patients in the control group were given Aspirin Entericcoated Tablets at 100 mg/d, and Atorvastatin Calcium Tablets for 40 mg/d. Patients in the observation group were iv administered with Salvianolic Acid for Injection on the basis of control group, 0.13 g/d was performed. Patients in two groups were treated with infusion for 2 weeks. The NIHSS score, Barthel index score and cerebral infarction volume of the two groups were observed and compared. Results At 1 month and 3 months after treatment, the NIHSS score in the control group was significantly decreased. 2 weeks, 1 month and 3 months after treatment, NIHSS scores in the observation group were significantly reduced, and the difference before and after treatment in the same group was statistically significant (P<0.01). After treatment of 2 weeks, 1 month and 3 months, NIHSS score in the observation group was significantly lower than that of the control group, and the difference between the two groups was statistically significant (P<0.01). After treatment of 1 month and 3 months, Barthel scores in two groups were significantly increased, and the difference before and after treatment in the same group was statistically significant (P<0.01). And the Barthel score of the observation group was significantly higher than that of the control group, and the difference between the two groups was statistically significant (P<0.01). The cerebral infarction volume of the control group was significantly decreased at 3 months after treatment, while that of the observation group was significantly decreased at 1 month and 3 months after treatment, with statistically significant difference before and after treatment in the same group (P<0.01). After 1 month of treatment, the cerebral infarction volume of the observation group was significantly lower than that of the control group, and the difference between the two groups was statistically significant (P<0.01). Conclusion Salvianolic Acid for Injection in treatment of massive cerebral infarction patients can reduce the mortality of patients, has a certain impact on the quality of life, neurological function recovery and infarction volume of patients.

R971