目的 評價注射用丹參多酚酸對辨證為血瘀型的急性腦梗死患者的臨床療效與安全性。方法 選取2018年7月-2019年7月安陽市中醫(yī)院收治的辨證為血瘀型的急性腦梗死患者85例，隨機分為對照組（43例）與觀察組（42例）。對照組給予調(diào)血壓、降血糖等基礎(chǔ)治療，觀察組在對照組基礎(chǔ)上加用注射用丹參多酚酸0.13 g溶于250 mL氯化鈉溶液中靜滴1次/d，兩組療程均14 d。比較兩組患者美國國立衛(wèi)生研究院卒中量表（NIHSS）、日常生活活動能力（ADL）評分、缺血半暗帶、臨床療效及不良反應(yīng)。結(jié)果 治療前兩組患者缺血半暗帶、NIHSS和ADL評分無統(tǒng)計差異。治療后，兩組患者缺血半暗帶、NIHSS和ADL評分均有改善（P<0.05），且觀察組這3個指標(biāo)改善程度均優(yōu)于對照組（P<0.05）；觀察組臨床總有效率為93%，明顯高于對照組的77%（P<0.05）；觀察組中醫(yī)血瘀證候療效的總有效率為95.2%，明顯高于對照組的72.0%（P<0.05）。兩組均無不良反應(yīng)發(fā)生。結(jié)論 注射用丹參多酚酸對血瘀型急性腦梗死患者的療效明顯，可能是基于對缺血半暗帶的有效治療而發(fā)揮神經(jīng)保護作用。

Objective To observe the clinical efficacy and safety of Salvianolic Acid for Injection in the treatment of acute cerebral infarction belong to blood stasis syndrome in traditional Chinese medicine. Methods A total of 85 patients with acute cerebral infarction belong to blood stasis syndrome in Traditional Chinese Medicine (TCM) in Anyang Traditional Chinese Medicine Hospital from July 2018 to July 2019 were selected and divided randomly into control group (43 cases) and observation group (42 cases). The control group was given antiplatelet aggregation, blood pressure and blood glucose control, free scavenger drugs. The observation group treated with Salvianolic Acid for Injection 0.13 g added into 250 mL sodium chloride injection for intravenous infusion once a day on the basis of control group. Both groups were treated for 2 weeks. The NIHSS scores, ADL scores, ischemic penumbra, therapeutic effects, and adverse reactions were compared between two groups before and after treatment. Results The NIHSS scores, ADL scores, and ischemic penumbra were no statistical difference between two groups before treatment. After treatment, the ischemic penumbra, NIHSS and ADL scores in two groups were improved (P<0.05), and the three indexes in observation group were better than those in control group (P<0.05). The clinical total effective rate in observation group was 93%, while it was 77% in control group, observation group was significantly higher than control group (P<0.05). The syndrome of blood stasis in TCM total effective rate in observation group was 95.2%, while it was 72.0% in control group, observation group was significantly higher than control group (P<0.05). There was no adverse reactions in two groups. Conclusion the therapeutic effect of Salvianolic Acid for Injection in the treatment of acute cerebral infarction is exact, which may be based on the effective treatment of ischemic penumbra after acute cerebral infarction and play a neuroprotective role.

R285.6;R286.1