瞬時(shí)受體電位4型（TRPV4）是一種非選擇性鈣離子滲透性通道，通過對(duì)細(xì)胞內(nèi)Ca²⁺的調(diào)節(jié)在許多生理和病理過程中發(fā)揮重要作用，其功能異?；蛉笔?huì)引起多種疾病。功能性TRPV4在人前脂肪細(xì)胞（即脂肪細(xì)胞前體細(xì)胞）中特別豐富，通過對(duì)細(xì)胞內(nèi)Ca²⁺的調(diào)節(jié)，在脂肪的合成、分解和調(diào)節(jié)脂質(zhì)穩(wěn)態(tài)過程中發(fā)揮重要作用。TRPV4還能有效地控制多種促炎基因的表達(dá)，參與胰島素抵抗的發(fā)展，并提供對(duì)高脂肪飲食引起肥胖的保護(hù)，可能是藥理學(xué)干預(yù)肥胖及相關(guān)代謝性疾病的一個(gè)非常重要的靶點(diǎn)。對(duì)TRPV4與脂肪代謝的關(guān)系做一綜述。

Transient receptor potential type 4 (TRPV4) is a calcium-permeable non-selective cation channel that plays an important role in many physiological and pathological processes through the regulation of intracellular Ca²⁺. Abnormal or absent function of TRPV4 can cause a variety of diseases. Functional TRPV4 is particularly abundant in human preadipocytes (ie, adipocyte precursor cells), which plays an important role in the synthesis, decomposition and regulation of lipid homeostasis by regulating intracellular Ca²⁺. Deletion of TRPV4 alters energy metabolism through an increase in calcineurin activity, leading to increased energy expenditure and providing protection against obesity caused by a high-fat diet, which may be a very important target for therapeutic pharmacological intervention. This paper reviews the relationship between TRPV4 and fat metabolism.

山西省自然基金一般項(xiàng)目（201601D102062）