目的 探索注射用丹參多酚酸對(duì)職業(yè)性急性化學(xué)物中毒性神經(jīng)系統(tǒng)疾病、輕度中毒性腦病患者的療效。方法 選取2018年6月—2019年6月于黑龍江省第二醫(yī)院住院的29例職業(yè)性急性化學(xué)物中毒性神經(jīng)系統(tǒng)疾病、輕度中毒性腦病患者作為研究對(duì)象，將患者隨機(jī)分為對(duì)照組（14例）和觀察組（15例）。對(duì)照組均給予常規(guī)治療，包括糾正腦缺氧、改善腦血循環(huán)、減輕腦水腫、降低顱內(nèi)壓等措施，觀察組在常規(guī)治療基礎(chǔ)上靜滴注射用丹參多酚酸，將注射用丹參多酚酸0.13 g加入到0.9%氯化鈉250 mL，1次/d。兩組療程為14 d。比較兩組患者治療前后顱內(nèi)段血管彩超血流速度及蒙特利爾認(rèn)知評(píng)估量表（MoCA）評(píng)分。結(jié)果 治療后，兩組患者血流速度均顯著改善（P<0.05）；且觀察組顱內(nèi)動(dòng)脈流速恢復(fù)明顯優(yōu)于對(duì)照組（P<0.05）。治療后，兩組MoCA評(píng)分均顯著升高（P<0.05）；且觀察組MoCA評(píng)分優(yōu)于對(duì)照組（P<0.05）。結(jié)論 在常規(guī)療法基礎(chǔ)上聯(lián)合注射用丹參多酚酸治療職業(yè)性急性化學(xué)物中毒性神經(jīng)系統(tǒng)疾病、輕度中毒性腦病，可有效改善顱內(nèi)段血管彩超血流速度，從而改善患者頭暈、頭痛等不適癥狀，并有效提高患者認(rèn)知功能。

Objective To explore the effect of Salvianolic Acid for Injection on patients with occupational acute chemical toxic neurological disease and mild toxic encephalopathy. Methods Patients (29 cases) with occupational acute chemical toxic neurological disease and mild toxic encephalopathy from June 2018 to June 2019 in the Second Hospital of Heilongjiang Province were divided into control (14 cases) and observation (15 cases) group. Patients in the control group was given routine treatment, including correction of cerebral hypoxia, improvement of cerebral blood circulation, alleviation of cerebral edema, and reduction of intracranial pressure, etc. Patients in the observation group were iv administered with Salvianolic Acid for Injection on the basis of control group, 0.13 g added into 0.9% sodium chloride 250 mL, once daily. Results After treatment, blood flow velocity in two groups was significantly improved (P < 0.05). And the intracranial arterial flow rate of the observation group was significantly better than that of the control group (P < 0.05). After treatment, MoCA scores in two groups were significantly increased (P < 0.05). And MoCA score in the observation group was better than that in the control group (P < 0.05). Conclusion Salvianolic Acids for Injection in treatment of patients with occupational acute chemotoxic nervous system disease and mild toxic encephalopathy on the basis of conventional therapy can effectively improve the blood flow velocity of intracranial vascular color doppler ultrasound, thereby improving the patient's dizziness, headache and other uncomfortable symptoms, and effectively improve the patient's cognitive function.

R969.4