中藥引起的不良反應中類過敏反應發(fā)生率逐年增高，對人類健康造成了嚴重的威脅。由于國內(nèi)外對類過敏反應發(fā)生的機制尚不完全清楚，評價方法尚不成熟，導致藥物類過敏反應的預測與評價存在不同程度的局限性。為了更好地了解類過敏反應，解決中藥致敏成分的研究與中藥注射劑的安全性評價問題，總結(jié)歸納了目前有關藥物誘導的類過敏反應發(fā)生機制及臨床前評價模型等內(nèi)容，通過對比分析，為后期深入研究提供依據(jù)和方法學指導。

The incidence of pseudo-allergy is the highest among the adverse drug reactions induced by Traditional Chinese Medicine (TCM), which threatens the public health seriously. The lack of research on mechanisms and evaluation models of pseudo-allergy results in different degrees of limitation on prediction and assessment on safety of drugs. In order to better understand the kind of allergic reaction, solve the allergic components and improve the safety of TCM, we summarize the mechanisms and evaluation models in vitro and in vivo of drug-induced pseudo-allergy for further study.

軍隊醫(yī)療機構(gòu)制劑標準提高科研專項（14ZJZ08）