口腔吸入及鼻用制劑（orally inhaled and nasal drug products，OINDPs）是指將藥物制備成干粉或霧滴，利用給藥裝置，分別將藥物運(yùn)送至肺部或鼻腔黏膜，進(jìn)而發(fā)揮局部或全身治療作用的劑型。噴霧模式和噴霧形態(tài)是溶液及混懸型吸入及鼻用制劑體外評(píng)價(jià)的重要指標(biāo)，可以采用激光成像系統(tǒng)進(jìn)行測(cè)定。對(duì)噴霧模式及噴霧形態(tài)的測(cè)定方法和結(jié)果評(píng)價(jià)進(jìn)行了詳細(xì)討論，同時(shí)對(duì)激光成像系統(tǒng)中自動(dòng)觸發(fā)器模塊的參數(shù)選擇進(jìn)行了相關(guān)說(shuō)明。

Orally inhaled and nasal drug products(OINDPs)refers to making drugs into powder or droplets, and delivering drug to the lungs or nasal mucous by using drug delivery device. OINDPs can give play to the role of local or systemic treatment dosage forms. Spray pattern and plume geometry are important indexes for evaluation of solution and suspension inhaled and nasal preparations in vitro, which can be determined by laser imaging system. The measurement methods and result evaluation of spray pattern and plume geometry are discussed in detail, and the parameter selection of automatic trigger module in laser imaging system is explained.