目的 研究艾迪注射液聯(lián)合?？颂婺嶂委煼切〖?xì)胞肺癌的效果。方法 選擇2015年6月-2018年6月榆林市第一醫(yī)院收治的84例非小細(xì)胞肺癌患者隨機(jī)分為兩組，每組42例。對(duì)照組采用鹽酸?？颂婺崞?，觀察組采用鹽酸埃克替尼片聯(lián)合艾迪注射液治療，50 mL/次，1次/d。1個(gè)療程為3周，均治療3個(gè)療程。比較兩組的生活質(zhì)量改善率、T細(xì)胞亞群水平和不良反應(yīng)情況。結(jié)果 治療后，觀察組的有效率為69.05%，顯著高于對(duì)照組的45.24%（P<0.05）。治療后，觀察組的生活質(zhì)量改善率為61.90%，顯著高于對(duì)照組的33.33%（P<0.05）。治療后，觀察組的CD8⁺、CD4⁺、CD3⁺和CD4⁺/CD8⁺水平均明顯高于治療前和對(duì)照組，差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）；對(duì)照組治療前后比較差異無統(tǒng)計(jì)學(xué)意義。觀察組白細(xì)胞下降、惡心嘔吐、血小板下降的發(fā)生率明顯低于對(duì)照組（P<0.05），兩組肝、腎功能異常率相比無明顯的差異。結(jié)論 艾迪注射液聯(lián)合?？颂婺釋?duì)非小細(xì)胞肺癌的效果較佳，能改善其CD細(xì)胞亞群水平和生活質(zhì)量，減輕不良反應(yīng)。

Objective To study the clinical effect of Aidi Injection combined with icotinib in treatment of non-small cell lung cancer. Methods Selected 84 cases of patients with non-small cell lung cancer from June 2015 to June 2018, divided into two groups randomly, and each group had 42 cases. The control group was treated with Icotinib Hydrochloride Tablets, 125 mg/time, three times daily. While the observation group was treated with Icotinib Hydrochloride Tablets combined with Aidi Injection, 50 mL/time, once daily. One course of treatment was 3 weeks, all of them were treated for 3 courses. The improvement rate of quality of life, the level of T cell subsets, and adverse reactions were compared between two groups. Results After treatment, the effective rate of the observation group was 69.05%, which was significantly higher than 69.05% in the control group (P<0.05). After treatment, the improvement rate of quality of life in the observation group was 61.90%, which was significantly higher than 33.33% in the control group (P<0.05). After treatment, the level of CD8⁺, CD4⁺, CD3⁺, and CD4⁺/CD8⁺ in the observation group after treatment was significantly higher than that before treatment and control group (P<0.05). There was no significant difference before and after treatment in the control group. The incidence of leukopenia, nausea, vomiting and thrombocytopenia in the observation group was significantly lower than control group (P<0.05). There was no significant difference in the abnormal rate of liver and kidney function between two groups. Conclusion Aidi Injection combined with Icotinib Hydrochloride Tablets has better effect on nonsmall cell lung cancer, can improve the level of T cell subsets and quality of life, and reduce adverse reactions.

陜西省社會(huì)發(fā)展科技攻關(guān)項(xiàng)目（2015SF057）