目的 探討血必凈注射液聯(lián)合鹽酸氨溴索分散片對腦卒中相關(guān)性肺炎患者炎性因子水平及預(yù)后的影響。方法 選取2016年5月-2018年5月洛陽市第三人民醫(yī)院76例腦卒中相關(guān)性肺炎患者為研究對象，根據(jù)隨機化原則將患者分為對照組和觀察組，每組各38例。對照組患者口服鹽酸氨溴索分散片，1片/次，3次/d。觀察組患者在對照組的基礎(chǔ)上將50 mL血必凈注射液加入到0.9%生理鹽水100 mL中靜脈滴注，2次/d，兩組均連續(xù)治療2周。比較兩組患者的臨床療效、治療前后血清各炎性因子水平及預(yù)后情況。結(jié)果 治療后，觀察組患者總有效率為94.74%，顯著高于對照組的78.95%（P<0.05）。治療后，兩組患者白細(xì)胞介素-6（IL-6）、白細(xì)胞介素-10（IL-10）、腫瘤壞死因子-α（TNF-α）、C反應(yīng)蛋白（CRP）及降鈣素原（PCT）水平較治療前均顯著下降（P<0.05），且觀察組顯著低于對照組（P<0.05）。觀察組患者神經(jīng)功能缺損程度（NIHSS）評分、急性生理和慢性健康（APACHEⅡ）評分、改良Rankin評分及病死率均顯著低于對照組（P<0.05）。結(jié)論 血必凈注射液聯(lián)合鹽酸氨溴索分散片可有效抑制機體炎性反應(yīng)，提高治療效果，對促進(jìn)腦卒中相關(guān)性肺炎患者病情康復(fù)、改善預(yù)后具有積極意義。

Objective To explore effect of Xuebijing Injection combined with Ambroxol Hydrochloride Dispersible Tablets on inflammatory factor levels and prognosis in patients with stroke-associated pneumonia. Methods Patients (76 cases) with strokeassociated pneumonia were selected as the subjects from May 2016 to May 2018 were divided into control and observation group according to randomization principles, and each group had 38 cases. Patients in the control group were treated with Ambroxol Hydrochloride Dispersible Tablets on the basis of stroke treatment, 1 tablet/time, three times daily. Patients in the observation group were treated with Xuebijing Injection on the basis of control group, 50 mL added into 0.9% saline 100 mL, twice daily. Patients in two groups were treated for 2 weeks. The clinical efficacy, serum levels of inflammatory factors and prognosis before and after treatment between two groups were compared. Results After treatment, the total effective rate of the observation group was 94.74%, which was significantly higher than 78.95% of the control group (P<0.05). After treatment, the levels of IL-6, IL-10, TNF-α, CRP, and PCT in two groups were significantly lower than those before treatment (P<0.05), and the observation group was lower than those in the control group (P<0.05). NIHSS score, APACHE II score, Rankin score, and mortality of the observation group were significantly lower than those of the control group (P<0.05). Conclusion Xuebijing Injection combined with Ambroxol Hydrochloride Dispersible Tablets can effectively inhibit the inflammatory reaction of the body, and improve the therapeutic effect. It is of positive significance to promote the recovery of patients with stroke-related pneumonia and improve the prognosis.