目的 觀察注射用丹參多酚酸對(duì)腦梗死急性期患者血清可溶性細(xì)胞間黏附分子-1（sICAM-1）、可溶性血管細(xì)胞黏附分子-1（sVCAM-1）表達(dá)的影響。方法 將126例腦梗死急性期患者隨機(jī)分為觀察組和對(duì)照組，對(duì)照組采用常規(guī)治療方法，進(jìn)行抗血小板治療：口服阿司匹林，每天100 mg，并輔以其他對(duì)癥支持治療。觀察組在常規(guī)治療基礎(chǔ)上加注射用丹參多酚酸100 mg，用250 mL生理鹽水稀釋，靜脈滴注，每天1次，連續(xù)14 d。應(yīng)用酶聯(lián)免疫吸附實(shí)驗(yàn)檢測(cè)兩組治療前后血清中sICAM-1和sVCAM-1水平。結(jié)果 兩組治療前血清中sICAM-1和sVCAM-1的水平比較差異無(wú)統(tǒng)計(jì)學(xué)意義。治療2周后觀察組血清中sICAM-1和sVCAM-1的水平與治療前比較均顯著降低（P<0.001），且顯著低于治療后對(duì)照組（P<0.001）。對(duì)照組治療前后無(wú)顯著差異。結(jié)論 注射用注射用丹參多酚酸對(duì)于腦梗死急性期患者血清中sICAM-1和sVCAM-1水平有明確的降低作用。

Objective Effect of Salvianolic Acid for Injection on expression of serum Soluble Intercellular Adhesion Molecule-1 (s ICAM-1) and Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) in patients with acute cerebral infarction. Methods Tatolly 126 patients with acute cerebral infarction were randomly divided into observation and control group. The control group was treated with routine therapy and antiplatelet therapy:oral aspirin, 100 mg per day, supplemented by other symptomatic supportive treatment. The observation group was treated with salvianolic acid 100 mg for injection, diluted with 250 mL saline, intravenously dripped once a day for 14 days. Enzyme-linked immunosorbent assay was used to examine the expression of sICAM-1 and sVCAM-1 in the serum of the two groups. Results There was no significant difference in the levels of sICAM-1 and sVCAM-1 between the two groups before treatment. The levels of sICAM-1 and sVCAM-1 in the serum of observation groups were significantly lower than those before treatment (P<0.05). The levels of sICAM-1 and sVCAM-1 in the serum of observation group were significantly lower compared with control group (P<0.05). Conclusions Salvianolic Acid for Injection has a clear effect on the levels of sICAM-1 and sVCAM-1 in the serum of patients with acute cerebral infarction.