參附注射液作為傳統(tǒng)方劑參附湯的現(xiàn)代用藥形式，在臨床發(fā)揮了重要作用。前期研究發(fā)現(xiàn)其對(duì)心血管系統(tǒng)疾病，包括心律失常，心力衰竭，失血性、感染性休克，再灌注損傷方面的保護(hù)作用。隨著研究不斷深入，還發(fā)現(xiàn)其對(duì)缺血腦損傷、神經(jīng)源性肺水腫、慢阻肺、腹膜透析參與腎功能、化療及麻醉術(shù)后不良反應(yīng)的改善作用，均有確切療效。作用機(jī)制主要涉及改善血流動(dòng)力學(xué)，抗炎、抗凝血、抗凋亡，改善代謝，增強(qiáng)免疫等多方面。就參附注射液的臨床應(yīng)用及藥理作用機(jī)制做一綜述，以期進(jìn)一步挖掘其潛在療效并更好地應(yīng)用于臨床。

As the main application forms of Shenfu Detection, ShenFu injection has played an important role in the clinical practice. In previous studies, we found that it plays a protective role in cardiovascular diseases, including arrhythmia, heart failure, hemorrhagic, septic shock and reperfusion injury. With the deepening of our research, we also found that it can improve the effects of ischemic brain injury, neurogenic pulmonary edema, chronic obstructive pulmonary disease and peritoneal dialysis on renal function, chemotherapy and adverse reactions after anesthesia. The mechanism of action mainly involves the improvement of hemodynamics, anti-inflammatory, anticoagulant, anti-apoptosis, improvement of metabolism, and enhancement of immune and other aspects. In this paper, the pharmacological action and specific mechanism of Shenfu injection are reviewed in order to further explore its potential efficacy and apply it to clinical practice.

國(guó)家自然科學(xué)基金資助項(xiàng)目（81473591，81573867）