可溶性鈣結(jié)合蛋白sorcin主要作用是調(diào)節(jié)細(xì)胞內(nèi)的鈣平衡，在腫瘤多藥耐藥（MDR）中起重要作用。Sorcin不僅自身可導(dǎo)致耐藥，而且可通過(guò)增加P-糖蛋白（P-gp）表達(dá)等途徑間接導(dǎo)致耐藥，因此可能在臨床對(duì)腫瘤的治療中成為逆轉(zhuǎn)腫瘤MDR的靶點(diǎn)。與sorcin相關(guān)的治療MDR的新方法包括反義寡核苷酸轉(zhuǎn)染技術(shù)、二氫楊梅素和鈣通道阻滯劑治療等。針對(duì)sorcin的作用機(jī)制和治療方法做一綜述，為臨床逆轉(zhuǎn)MDR提供依據(jù)。

The main function of sorcin is to regulate intracellular calcium balance and play an important role in multidrug resistance of tumors. Sorcin not only causes drug resistance in itself, but also indirectly leads to drug resistance by increasing the expression of P-gp. Therefore, Sorcin can be clinically used as a target for reversing the multidrug resistance. New methods for the treatment of MDR associated with sorcin include antisense oligonucleotide transfection techniques, treating with dihydromyricetin and calcium channel blocker, and so on. This article reviews the mechanisms and therapies for sorcin so as to provides the basis for the clinical reversal of MDR.

國(guó)家自然科學(xué)基金資助項(xiàng)目（81473280）