目的 探討氨氯地平貝那普利對糖尿病合并高血壓患者動態(tài)血壓的影響及腎臟保護(hù)作用。方法 105例糖尿病合并高血壓患者隨機(jī)分為3組，每組35例，A組單用氨氯地平治療，劑量10 mg/次，每日1次，每日6：00-8：00服藥；B組單用鹽酸貝那普利片進(jìn)行治療，劑量20 mg/次，每日1次，每日6：00-8：00服藥；C組應(yīng)用氨氯地平貝那普利片進(jìn)行治療，口服，15 mg/次，每日1次，每日6：00-8：00服藥，均持續(xù)用藥3個月。對比3組患者治療前后的動態(tài)血壓指標(biāo)及腎功能指標(biāo)變化，并觀察兩組治療期間的不良反應(yīng)。結(jié)果 3組患者用藥1、3個月的24 h平均收縮壓（SBP）、舒張壓（DBP）值均較用藥前降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且C組用藥1、3個月的24 h平均SBP、DBP值均顯著低于A、B兩組，組間差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。3組患者用藥1、3個月的尿微量白蛋白排泄率比較有顯著性差異，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且C組用藥1、3個月的尿微量白蛋白排泄率均顯著低于A、B兩組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。3組患者的不良反應(yīng)均較輕微，未進(jìn)行特殊處理，不影響持續(xù)治療。3組的不良反應(yīng)發(fā)生率對比無顯著差異。結(jié)論 氨氯地平貝那普利治療糖尿病合并高血壓，能夠有效降低血壓水平改善臨床癥狀，發(fā)揮腎臟保護(hù)作用，且無明顯不良反應(yīng)。

Objective To explore the effects of amlodipine benazepril treatment of diabetic hypertension on ambulatory blood pressure and renal protection. Methods 105 patients with diabetes mellitus were randomly divided into three groups (n=35). Group A was treated with amlodipine alone. Group B was treated with benazepril alone. Group C was treated with amlodipine benazepril. To compare the ambulatory blood pressure index and renal function index changes of three groups before and after treatment. Results The 24 h mean SBP and DBP of the three groups were significantly lower than those of the control group after treatment 1 month and 3 months (P<0.05), and the difference was significant (P<0.05). The 24 h mean SBP and DBP of group C were significantly lower than those of group A and group B after treatment 1 month and 3 months (P<0.05).Three groups of patients with urinary microalbumin excretion rate was significantly different after treatment 1 month and 3 months, and the rate of urinary albumin excretion in group C was significantly lower than that in group A and B after treatment 1 month and 3 months (P<0.05). The adverse reactions of the three groups were mild, and no special treatment was carried out, which did not affect the continuous treatment. There was no significant difference in the incidence of adverse reactions between the three groups. Conclusion Amlodipine benazepril treatment of diabetic hypertension can effectively reduce the level of blood pressure to improve clinical symptoms, play a protective role in the kidney, and no significant adverse reactions.