缺血性腦損傷常見的并發(fā)癥為缺血性腦水腫，后者與血腦屏障（BBB）的功能密切相關(guān)。體外研究顯示血管內(nèi)皮生長(zhǎng)因子（VEGF）能與受體結(jié)合從而激活多種細(xì)胞信號(hào)通路，通過抑制細(xì)胞調(diào)亡、降低氧化應(yīng)激而發(fā)揮腦保護(hù)作用。蝮龍抗栓丸、參附注射液、腦泰通顆粒等中藥可通過調(diào)控VEGF治療BBB損傷。圍繞VEGF及其相關(guān)通路在缺血性腦損傷中的研究進(jìn)展及中藥通過干預(yù)VEGF及其相關(guān)通路治療BBB損傷做一綜述，為腦缺血異常的臨床治療及新藥研發(fā)提供理論依據(jù)。

The common complication of ischemic brain injury was ischemic brain edema, which was closely related to the function of the blood-brain barrier (BBB). In vitro studies,which have shown that vascular endothelial growth factor (VEGF) could bind to the receptor to activate a variety of cell signaling pathways, by inhibiting cell apoptosis, reduce oxidative stress and play a protective role in the brain. Fulong Antithrombotic Pill,Shenfu Injection,Naotaitong Granule and others traditional Chinese medicine can regulate the treatment of BBB injury by VEGF regulation. This article reviewde the study progress of VEGF and its related pathways in ischemic brain injury,and the treatment of BBB injury by Chinese medicine by interventional VEGF and its related pathways,which provide a theoretical basis for the clinical treatment of cerebral ischemic abnormalities and the development of new drugs.