目的評(píng)價(jià)殼聚糖對(duì)臨床手術(shù)創(chuàng)面修復(fù)的有效性及安全性。方法檢索Cochrane圖書館臨床對(duì)照試驗(yàn)資料庫(kù)（CCTR）,Medline、Embase、PubMed數(shù)據(jù)庫(kù),中國(guó)期刊全文數(shù)據(jù)庫(kù)（CNKI）、萬(wàn)方數(shù)字化期刊全文庫(kù)、中文科技期刊全文數(shù)據(jù)庫(kù)（VIP）和中文生物醫(yī)學(xué)期刊文獻(xiàn)庫(kù)（CMCC）,收集殼聚糖修復(fù)手術(shù)創(chuàng)面的隨機(jī)對(duì)照臨床試驗(yàn),使用RevMan 5.0軟件進(jìn)行Meta分析。結(jié)果共納入16項(xiàng)研究,3 414例患者。Meta分析結(jié)果顯示：殼聚糖對(duì)手術(shù)創(chuàng)面修復(fù)的愈合時(shí)間明顯短于對(duì)照組[WMD=-0.64,95%CI（-0.69~-0.59）,P<0.000 01],且能更好地促進(jìn)切口愈合[RR=1.03,95%CI（1.01~1.04）,P=0.0002]；明顯減輕術(shù)后疼痛[WMD=-3.49,95%CI（-5.07~-1.91）,P<0.000 1]；減少術(shù)后感染[RR=0.49,95% CI：0.33~0.71,P=0.000 2]。結(jié)論殼聚糖能縮短術(shù)后傷口愈合時(shí)間,更好地促進(jìn)傷口愈合,減輕疼痛,減少感染；但納入的研究質(zhì)量均不高,仍亟需更多高質(zhì)量的臨床試驗(yàn)進(jìn)一步驗(yàn)證殼聚糖對(duì)臨床手術(shù)后創(chuàng)面修復(fù)的有效性和安全性。

Objective To evaluate the efficacy and safety of chitosan in the repair of clinical surgery wounds. Methods The databases of Cochrane Controlled Trials Register (CCTR), Embase database, Medline database, PubMed database, CNKI database, WanFang database, VIP database and Chinese Biomedical Journal Library (CMCC) were retrieved with computer for collecting randomized controlled trials (RCT) about the repair clinical surgery wounds healing. Meta-analysis on all the data are carried out by RevMan 5.0 software. Results There were totally 16 trials and 3414 patients included. The results showed that the wound healing time of chitosan was significantly shorter than that of the control group[WMD=-0.64, 95%CI (-0.69~-0.59), P < 0.000 01], and chitosan can better promote wound healing[RR=1.03, 95%CI (1.01~1.04), P=0.0002]. In experimental group, postoperative pain were reliever[WMD=-3.49, 95%CI (-5.07~-1.91), P < 0.0001], and postoperative infection were reduced[RR=0.49, 95%CI (0.33~0.71), P=0.0002]. Conclusion The existing evidences indicate that chitosan can shorten postoperative wound healing time, promote wound healing, relieve pain, and reduce infection. However, the study is limited by the quality of included literature, more clinical trials should be done to confirm the effective and safety.

福建省科技廳高校產(chǎn)學(xué)合作項(xiàng)目（2015Y4006）；福建中醫(yī)藥大學(xué)校管課題（XB2015001）