目的 系統(tǒng)評價坦度螺酮與丁螺環(huán)酮治療廣泛性焦慮癥的療效與安全性。方法 計算機檢索PubMed、中國期刊全文數(shù)據(jù)庫（CNKI）、中國生物醫(yī)學文獻數(shù)據(jù)庫（CBM）、萬方數(shù)據(jù)庫、中文科技期刊全文數(shù)據(jù)庫（VIP），收集坦度螺酮與丁螺環(huán)酮治療廣泛性焦慮癥的隨機對照研究（RCT），檢索時限為2000年1月至2016年6月，并追溯納入研究的參考文獻。2位研究者按照納入與排除標準獨立篩選文獻、提取資料和評價文獻質(zhì)量后，用RevMan5.0軟件對各效應指標進行Meta分析。結果 共納入7篇RCT，合計615例廣泛性焦慮癥患者。Meta分析結果顯示：坦度螺酮（試驗組）與丁螺環(huán)酮（對照組）在顯效率[P=0.34，OR=1.19，95% Cl（0.83～1.69）]與HAMA評分方面[P=0.80，MD=-0.08，95% Cl（-0.72～0.56）]差異無統(tǒng)計學意義（P>0.05）；2組頭暈、口干、便秘、失眠、食欲減退、惡心發(fā)生率差異無統(tǒng)計學意義（P>0.05）。結論 坦度螺酮與丁螺環(huán)酮治療廣泛性焦慮癥療效相當，常見不良反應發(fā)生風險相似。

Objective To evaluate the therapeutic effect and safety of tandospirone and buspirone in the treatment of generalized anxiety disorder. Methods The clinical control study of tandospirone and buspirone in the treatment of generalized anxiety disorder was earched by PubMed, CBM, CNKI, VIP, and Wanfang Data, with deadline from January 2000 to June 2016. Meta-analysis was carried out using RevMan5.0 software to each effect index. Results A total of seven RCTs were included involving 615 patients were identified. Meta-analysis showed that the significant efficiency rate[P=0.34, OR=1.19, 95%CI (0.83~1.69)] and HAMA[P=0.80, MD=-0.08, 95%CI (-0.72~0.56)] of tandospirone and buspirone had no significant difference. Two groups of adverse drug reactions, dizzy, dry, constipine, insomnia, anorexia, and nausea had no significant difference (P>0.05). Conclusion The efficacy and adverse reaction of tandospirone and buspirone in the treatment of generalized anxiety disorder are fairly.

重慶市社會事業(yè)與民生保障科技創(chuàng)新專項計劃項目（cstc2015shmszx120073）；重慶市萬州科技計劃基金資助項目（201403055）