目的 探討分析凍干重組人腦利鈉肽對心肌梗死合并心力衰竭患者血管內(nèi)皮功能和炎癥因子的影響。方法 選擇2012年3月-2016年3月漢中市中心醫(yī)院收治的266例心肌梗死合并心力衰竭患者，隨機(jī)分為對照組（128例）和觀察組（138例）。對照組給予常規(guī)藥物治療，觀察組在對照組的基礎(chǔ)上靜脈滴注凍干重組人腦利鈉肽3～5 d。觀察比較兩組患者的血管內(nèi)皮功能、炎癥因子的變化，以及治療總有效率。結(jié)果 治療后2周，觀察組患者的內(nèi)皮依賴性血管舒張功能（FMD）顯著高于對照組（P<0.05）；觀察組的血清NO顯著高于對照組，內(nèi)皮素1顯著低于對照組（P<0.05）；治療5 d后，觀察組患者的血清C反應(yīng)蛋白（CRP）、白細(xì)胞介素-6（IL-6）及血清腫瘤壞死因子（TNF-α）均顯著低于對照組，差異具有統(tǒng)計學(xué)意義（P<0.05）；觀察組患者的治療總有效率為89.1%，顯著高于對照組的60.2%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 凍干重組人腦利鈉肽可促進(jìn)血清NO的升高，抑制內(nèi)皮素1的升高，利于心肌梗死合并心力衰竭患者血管內(nèi)皮功能的改善，抑制炎癥因子的釋放而進(jìn)一步改善其心功能。

Objective To investigate the effect of natriuretic peptide on vascular endothelial function and inflammatory factors of patients with heart failure complicating myocardial infarction. Methods Two hundred and twenty-six patients with heart failure complicating myocardial infarction admitted into Hanzhong Central Hospital from March 2012 to March 2016 were randomly divided into experimental group (n=138) and control group (n=128). Patients in control group were treated with conventional drug, and patients in experimental group were treated with natriuretic peptide based on conventional drug treatment. The vascular endothelial function, contents of NO and eddthelin 1, and inflammatory factors including CRP, IL-6, and TNF-α were detected. Results After 2 weeks of treatment, the flow-mediated vasodilation (FMD) and NO in experimental group were remarkably higher than those in control group, and eddthelin 1 was significantly lower than those of control group (P<0.05). Additionally, CRP, IL-6, and TNF-α in experimental group were significantly lower than those in control group after treatment for 5 d (P<0.05). Conclusion Natriuretic peptide could improve the vascular endothelial function of patients with heart failure complicating myocardial infarction via increasing the content of NO and decreasing content of eddthelin 1, and was benefit to cardiac function by inhibiting release of inflammatory factors.