目的 建立加味逍遙方中無機元素的微波消解-電感耦合等離子體質(zhì)譜（ICP-MS）分析方法，對不同批次加味逍遙提取物和組方藥材中無機元素進行比較和分析。方法 采用微波消解法對樣品進行前處理，ICP-MS法對加味逍遙提取物中鐵、鋅、銅、錳、鎳、釩、鉻、鈷、硒、鍶、銫、砷、鎘、銀、汞、鉛、鈾20種無機元素的進行了定量，并應(yīng)用SPSS 22.0軟件對結(jié)果進行統(tǒng)計學(xué)分析。結(jié)果 加味逍遙提取物中20種無機元素之間具有一定的相關(guān)性，應(yīng)用主成分分析選出4個主因子，得出Na、Mg、Al、V、Ni、Cu、Se、Sr、Cs、Mn、Hg、Fe為加味逍遙提取物的特征元素；組方藥材中主要含有Mg、Al、Mn、Fe；10味藥材因其藥用部位不同無機元素水平差異較大，同種元素水平從根及根莖類、皮類、全草類、果實種子類、菌類依次降低。結(jié)論 無機元素的水平變化不僅能表征提取工藝過程的穩(wěn)定性，而且能為中藥復(fù)方配伍規(guī)律研究提供實驗依據(jù)。

Objective To study the distribution and correlation of 20 kinds of inorganic elements (Na, Mg, Al, V, Cr, Co, Fe, Ni, Cu, Zn, Mn, As, Se, Cd, Cs, Sr, Ag, Hg, Pb, and U) in Jiawei Xiaoyao Formula (JXF). Methods The levels of 20 inorganic elements in 10 kinds of herbal substances were determined by ICP-MS with microwave digestion for sample preparation, and the results were analyzed with SPSS22.0. Results There were some correlations among the inorganic elements in JXF; Four main factors were selected by principal component analysis (PCA). The PCA results showed that Na, Mg, Al, V, Ni, Cu, Se, Sr, Cs, Mn, Hg, and Fe might be the characteristic elements in JXF; There were Mg, Al, Mn, and Fe elements in 10 herbal drugs, the contents of inorganic elements in herbal drug were different because the medicinal parts were different, and the decreasing order was roots and rhizomes, skin type, all grass, fruit seeds, and fungi. Conclusion Contents of inorganic elements can not only characterize the stability of extraction process, and can provide experimental evidence for the study of traditional Chinese medicine compound compatibility law.