目的 研究含對乙酰氨基酚的西藥對乙酰氨基酚片、復方氨酚烷胺片、美撲偽麻片及中成藥柴芩清寧膠囊對脂多糖（LPS）及干酵母大鼠發(fā)熱模型的解熱作用。方法 制備大鼠100 μg/kg LPS及20%干酵母發(fā)熱模型；乙酰氨基酚片、復方氨酚烷胺片、美撲偽麻片高、中、低劑量分別為205.67、102.83、51.42 mg/kg，以對乙酰氨基酚計；柴芩清寧膠囊高、中、低劑量分別為1110.60、555.30、277.65 mg/kg，以膠囊內容物質量表示，ig給藥。觀察大鼠體溫變化，計算平均最大體溫上升高度（△T）及體溫反應指數（TRI），繪制平均升溫曲線。結果 對乙酰氨基酚片、復方氨酚烷胺片、美撲偽麻片及柴芩清寧膠囊各劑量組對LPS及干酵母大鼠發(fā)熱模型均具有顯著解熱作用，且均存在一定劑量效應關系。結論 對乙酰氨基酚片、復方氨酚烷胺片、美撲偽麻片及柴芩清寧膠囊對LPS及干酵母大鼠發(fā)熱模型均有一定解熱作用，3種西藥的解熱作用起效快但是作用時間短，而柴芩清寧膠囊表現為起效慢但是作用時間長。

Objective To study the antipyretic effect of Paracetamol Tablets, Compound Paracetamol and Amantadine Hydrochloride Tablets, Compound Dextromethorphan Hydrobromide Tablets, and Chaiqin Qingning Capsules on the fever model induced by LPS and dry yeast in rats.Methods Fever was induced by ip injecting LPS (100 μg/kg) or sc injecting dry yeast (20%) in rats. We observed the changes of temperature of the rats after administration of Paracetamol Tablets, Compound Paracetamol and Amantadine Hydrochloride Tablets, Compound Dextromethorphan Hydrobromide Tablets (the acetaminophen contents were 205.67, 102.83, and 51.42 mg/kg) and Chaiqin Qingning Capsules (1110.60, 555.30, and 277.65 mg/kg). Maximum temperature rise height (△T) and temperature response index (TRI) were calculated, and the curve of average rise in temperature was drawn.Results Each dose group of Paracetamol Tablets, Compound Paracetamol and Amantadine Hydrochloride Tablets, Compound Dextromethorphan Hydrobromide Tablets, and Chaiqin Qingning Capsules had obvious antipyretic effect on the fever model induced by LPS and dry yeast in rats, and there was a certain dose-effect relationship.Conclusion Paracetamol Tablets, Compound Paracetamol and Amantadine Hydrochloride Tablets, Compound Dextromethorphan Hydrobromide Tablets, and Chaiqin Qingning Capsules has certain antipyretic effect on LPS and dry yeast fever model in rats, and on the whole, the Western medicine acts rapid but continue for a short time, while the traditional Chinese medicine acts slow but continues for a long time.