目的 探討疏肝解郁膠囊聯(lián)合蘭索拉唑和莫沙必利治療伴有抑郁焦慮狀態(tài)的功能性消化不良的臨床效果。方法 選取2012年12月—2014年6月106例伴抑郁焦慮狀態(tài)的功能性消化不良患者為研究對(duì)象,隨機(jī)分成2組,對(duì)照組53例,予聯(lián)合蘭索拉唑和莫沙必利;觀(guān)察組53例,在對(duì)照組的基礎(chǔ)上加用疏肝解郁膠囊治療,觀(guān)察治療后療效、不良反應(yīng)等指標(biāo)變化情況。結(jié)果 療效上,對(duì)照組痊愈率為24.53%、總有效率為79.25%,觀(guān)察組痊愈率為39.62%、總有效率為94.34%,觀(guān)察組在痊愈率和總有效率上顯著優(yōu)于對(duì)照組(P<0.05);兩組治療后在抑郁、焦慮評(píng)分上均較治療前顯著下降,治療前后比較差異顯著(P<0.05),治療后觀(guān)察組抑郁、焦慮評(píng)分顯著優(yōu)于對(duì)照組(P<0.05);兩組治療后NOS較治療前顯著下降,5-HT較治療前顯著升高,治療前后比較差異顯著(P<0.05),治療后觀(guān)察組5-HT、NOS顯著優(yōu)于對(duì)照組(P<0.05);對(duì)照組睡眠障礙、頭暈、便秘等不良反應(yīng)發(fā)生率為58.49%,觀(guān)察組睡眠障礙、頭暈、便秘等不良反應(yīng)發(fā)生率為20.75%,觀(guān)察組顯著低于對(duì)照組,兩組比較差異顯著(P<0.05)。結(jié)論 疏肝解郁膠囊聯(lián)合蘭索拉唑和莫沙必利治療伴有抑郁焦慮狀態(tài)的功能性消化不良臨床療效滿(mǎn)意。

Objective To investigate the clinical efficacy of Shugan Jieyu Capsule (SJC) in treatment of functional dyspepsia combined with depression and anxiety state, in order to improve the clinical efficacy. Methods Patients (106 cases) with liver resolve depression capsule in treatment of functional dyspepsia combined with depression and anxiety state were chosen as two groups, the control group had 53 cases, who were given Western medicine treatment, the observation group were taken with liver resolve depression capsule on the base of control group. The efficacy, adverse reaction after treatment were observed. Results The cure rate of control group was 24.53%, the total efficacy was 79.25%, while those in the observation group were 39.62% and 94.34%, the observation group was higher than the control group (P < 0.05). Compared with that before treatment, the depression anxiety score of two groups after treatment were obviously decreased (P < 0.05). The depression and anxiety score was greater than that in the control group (P < 0.05), the NOS of two group were significant lower than those before treatment, the 5-HT was obviously higher (P < 0.05), compared with control group, the 5-HT and NOS of observation group were higher than the control group (P < 0.05), the adverse reaction of sleep disturbance, dizziness, constipation of control group was 58.49%, the observation group was 20.75%, the control group was significant lower than the control group (P < 0.05). Conclusion The SJC in treatment of functional dyspepsia combined with depression and anxiety state has great clinical efficacy.