目的 觀察毛菊苣提取物抗慢性肝纖維化的作用。方法 將Wistar大鼠隨機(jī)分為毛菊苣提取物低、中、高劑量（50、100、150 mg/kg）組，秋水仙堿（colchicine，0.5 mg/kg）組，模型組和正常組，ig給藥。給藥同時(shí)各組sc四氯化碳（CCl₄）造模，每周2次。于60 d后，檢測(cè)大鼠血清丙氨酸氨基轉(zhuǎn)移酶（ALT）、天冬氨酸氨基轉(zhuǎn)移酶（AST）、總蛋白（TP）、白蛋白（ALB）、肝組織丙二醛（MDA）、谷胱甘肽過(guò)氧化物酶（GSH-Px）、羥脯氨酸（Hyp）及肝組織病理變化。結(jié)果 與模型組比較，毛菊苣提取物低、中、高劑量組均能明顯降低肝纖維化大鼠血清中ALT、AST的含量及肝組織中MDA和Hyp的含量（P＜0.01），明顯提高血清TP、ALB水平（P＜0.05、0.01）及肝組織GSH-Px活性（P＜0.01）；肝臟組織學(xué)檢查表明，毛菊苣提取物可明顯改善肝組織病理?yè)p傷程度，其作用呈一定的量效關(guān)系。結(jié)論 毛菊苣提取物對(duì)實(shí)驗(yàn)性慢性肝損傷具有保護(hù)肝細(xì)胞，減少肝損傷，抗肝纖維化作用。

Objective To investigate the effects of Cichorium glandulolsum extract (CGE) on liver fibrosis induced by chronic hepatic injury. Methods Wistar rats were randomizedly divided into six groups: CGE (50, 100, and 150 mg/kg) treatment groups, colchicine (Colc, 0.5 mg/kg) treatment group, model group, and normal control group. Rats were sc injected with carbon tetrachloride (CCl₄) two times a week to induce liver fibrosis as well as ig administration of CGE or Colc. After 60 d, the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP), albumin (ALB) in serum and malondialdehyde (MDA), glutathione peroxidase (GSH-Px), hydroxyproline (Hyp) in liver tissue were determined, and the liver histological changes were investigated by pathological examination. Results Compared with the model group, CGE significantly reduced the levels of ALT and AST in serum (P < 0.01), and decreased MDA and Hyp levels in liver tissue (P < 0.01) while TP, ALB, and GSH-Px were significantly elevated (P < 0.05, 0.01). Pathological examination revealed that CGE had the therapeutical effect on the experimental liver fibrosis. Conclusion CGE has the better effects on protecting hepatocyte, relieving liver injury, and against liver fibrosis.