目的 探討氟哌噻噸美利曲辛片致不良反應(yīng)的一般規(guī)律與特點(diǎn)。方法 檢索2000年1月—2013年3月國(guó)內(nèi)醫(yī)藥期刊報(bào)道的氟哌噻噸美利曲辛片所致不良反應(yīng)案例，并進(jìn)行統(tǒng)計(jì)分析。結(jié)果 氟哌噻噸美利曲辛片致不良反應(yīng)在老年患者發(fā)生率較高，多在用藥1周后發(fā)生。不良反應(yīng)累及多個(gè)系統(tǒng)–器官，臨床表現(xiàn)復(fù)雜多樣，主要表現(xiàn)為泌尿系統(tǒng)損害和全身性損害，嚴(yán)重者可出現(xiàn)死亡。結(jié)論 臨床上應(yīng)重視氟哌噻噸美利曲辛片的不良反應(yīng)，堅(jiān)持合理用藥。

Objective To investigate the general rules and characteristics of adverse drug reactions (ADR) induced by Flupentixol and Melitracen Tablets. Methods To collecte the characteristics and related factors of ADR induced by Flupentixol and Melitracen Tablets reported in domestic medical journals during January, 2000—March, 2013 and analyze statistically. Results Flupentixol and Melitracen Tablets caused ADR in aging patients with a higher incidence of more than 1 week after treatment. ADR involving multiple systems- organs, clinical manifestations of complex and diverse, mainly for the urinary system damage and systemic damage, there may be serious death. Conclusion The clinical attention should be paid to Flupentixol and Melitracen Tablets ADR, adhere to the rational use of drugs.