類風(fēng)濕性關(guān)節(jié)炎（rheumatoid arthritis，RA）是一種以關(guān)節(jié)滑膜炎、破壞性關(guān)節(jié)病變?yōu)橹饕卣鞯穆?、進(jìn)行性、侵襲性自身免疫性疾病，致畸、致殘率極高且大多數(shù)患者反復(fù)發(fā)作。目前，改善臨床癥狀的抗風(fēng)濕藥是治療RA的主要手段，但由于傳統(tǒng)抗風(fēng)濕藥的不良反應(yīng)較大，而生物制劑價(jià)格昂貴，因而患者長(zhǎng)期服用依從性差，不利于疾病控制。因此研制開發(fā)有效、不良反應(yīng)小的抗風(fēng)濕藥物勢(shì)在必行。研究并建立合理有效的RA動(dòng)物模型是研制開發(fā)有效治療藥物和制訂有效治療措施的關(guān)鍵，而正確的檢測(cè)也能準(zhǔn)確地反映出藥物的療效。因此以Wistar大鼠為試驗(yàn)動(dòng)物，對(duì)其進(jìn)行免疫，從關(guān)節(jié)炎指數(shù)評(píng)定、血清學(xué)、病理學(xué)和影像學(xué)檢測(cè)等方面進(jìn)行綜合評(píng)價(jià)，從而測(cè)評(píng)抗風(fēng)濕藥物藥效。

Rheumatoid arthritis (RA) is a chronic, progressive, and aggressive autoimmune disease, the main characters of which include joint synovial inflammation and destructive arthropathy. RA is teratogenic and most of the patients are with high morbidity repeated attacks in the duration of symptoms. At present, medicine to improve the clinical symptoms of rheumatism is the main treatment for RA. But because of the side effects of traditional medicine and the cost of biological agents, patients have poor compliance in long-term use and there are difficulties in disease control. Therefore it is imperative to develop effective antirheumatic agents, with small side effects. To study and establish an effective rheumatoid arthritis animal model is the key to develop effective drugs and make effective treatment measures. Appropriate testing also could reflect the therapeutic efficacy of drugs accurately. So Wistar rats on the immune were used as test animals, and arthritis index evaluation, serologic, pathologic, and iconographic detection were carried out so as to evaluate the potency of antirheumatic agents.

安徽省教育廳自然科學(xué)自籌重點(diǎn)項(xiàng)目(100408)