環(huán)糊精包合技術和緩控釋技術是發(fā)展較快的釋藥技術，分子模擬技術在這兩種釋藥技術中的應用也越來越多。簡述環(huán)糊精包合技術和緩控釋釋藥技術的優(yōu)點、影響因素和釋藥原理，介紹幾種重要的分子模擬技術在環(huán)糊精包合技術和緩控釋釋藥技術中的應用，并給出了分子模擬技術在具體應用中的力場及模擬的條件，分析分子模擬技術的在環(huán)糊精包合技術和緩控釋技術中應用的優(yōu)點和難點，展望分子模擬在其應用中的前景，指出分子模擬技術有望成為研究釋藥技術的一種常規(guī)項的工具。

In recently year, technology of cyclodextrin inclusion and controlled release drug delivery systems have been developed at top speed, especially, the research of drug delivery technology by using molecular dynamics simulation as well as has grown rapidly. This review describes the advantages and influencing factors about the technology of cyclodextrin inclusion and controlled release drug delivery, introduces the methods of the molecular dynamics simulation and system of field force applied in those researches, evaluates of the status of their application. Based on those, author points out the outlook in the future study.

國家重點基礎研究發(fā)展計劃項目（2010CB735602）；國家重大新藥創(chuàng)制專項（2011ZX09401-009，2010ZX09401-307-1-1）