目的：探討甘草酸協(xié)同麻黃堿的平喘作用機制。方法：利用基于CHO細胞的β₂腎上腺素受體（β₂-AR）激動藥活性評價體系，豚鼠離體氣管收縮和組胺引喘的活體動物模型觀察甘草酸和麻黃堿聯(lián)用的協(xié)同平喘效果。結果：甘草酸自身不能引起離體氣管平滑肌舒張，平喘效果也不顯著，但與麻黃堿聯(lián)用可以通過提高β₂-AR的激動效果，明顯增強平喘效果。結論：甘草酸通過調節(jié)β₂-AR信號通路增強麻黃堿的作用效果，兩者聯(lián)用有良好的協(xié)同作用。

Objective: To investigate the anti-asthmatic mechanism of combination of glycyrrhizic acid and ephedrine. Methods: With cell evaluating systems of β₂ adrenergic receptor (β₂-AR) agonists established by our laboratory, model of spasmolytic activities in vitro and antitussive activities in vivo, the effect of combination use of glycyrrhizic acid and ephedrine was observed. Results: In our study, glycyrrhizic acid alone showed little anti-asthmatic effect and could not relax the airway smooth muscles. However, it could enhance the anti-asthmatic activity of ephedrine when these two compounds were used together. Conclusion: Glycyrrhizic acid could increase bronchodilation activity of ephedrine through β₂-AR signal pathway and has synergistic effect on anti-asthmatic treatment.