目的：研究何首烏中提取出的鞣質(zhì)對(duì)大鼠肝臟生化指標(biāo)的影響。方法：每天按不同劑量（分別相當(dāng)于成人每日30 g/60 kg體質(zhì)量臨床用量的25、50、100倍）ig大鼠1次，連續(xù)給藥90 d，恢復(fù)期15 d。分別于第60、90、105 天采取動(dòng)物血液進(jìn)行生化指標(biāo)的檢測(cè)。結(jié)果：給藥組與對(duì)照組相比，給藥60 d時(shí)大鼠血清中 ALT大劑量組顯著升高（P＜0.01），中劑量組升高（P＜0.05）；ALP中、小劑量組有所降低（P＜0.05）；TG大劑量組升高（P＜0.05）；GGT大、小劑量組升高（P＜0.05）；TBIL大、中、小劑量組均顯著性降低（P＜0.01）。給藥90 d后大劑量組大鼠血清ALT、 GGT均升高（P＜0.05）?；謴?fù)15 d后各項(xiàng)指標(biāo)與對(duì)照組均無(wú)顯著差異。結(jié)論：何首烏中提取的鞣質(zhì)長(zhǎng)期ig大劑量對(duì)大鼠肝臟有損害，中劑量短期內(nèi)對(duì)肝臟有所損害，小劑量無(wú)明顯肝損害，但其對(duì)肝臟的損害在停藥后均可以恢復(fù)。

Objective: To study the effects of tannin in Polygonum multiflorum on rats' biochemical indexes in liver of rats. Methods: The rats were drenched with different dosages of tannin once daily, that are 25, 50, and 100 times of the amount of an adults' clinical dosage-30 g/60 kg body weight, respectively. It was successively ig administered for 90 d, and the recovery period was 15 d. The rats' blood samples were taken on the dau 60, 90, and 105, respectively for the blood biochemical parameters examination. Results: Compared the experimental groups with the control group, the medicine had some effects on rat serum in 60 d, ALT of high-dose group was significantly increased (P＜0. 01) and medium dose group elevated (P＜0. 05); ALP medium and small-dose groups were lower (P＜0. 05); TG of high-dose group was increased (P＜0. 05); All TBIL were significantly decreased (P＜0. 01), ALT and GGT of high-dose groups in rat serum by ig administration for 90 d were increased (P＜0. 05) . Conclusion: Tannin in P. multiflorum could make rat liver damaged when drenched with long-term and large quantity dosages, the medium dose damages rat liver shortly, and the small dose does no significant damage. Meanwhile all of them could be restored after the withdrawal of tannin in P. multiflorum.