目的：研究乳舒片對(duì)大鼠乳腺增生及激素分泌的影響。方法：大鼠隔日ip苯甲酸雌二醇，連續(xù)6周，復(fù)制大鼠乳腺增生模型。應(yīng)用乳舒片（高、中、低3個(gè)劑量組）處理模型大鼠4周，測(cè)定第1、2對(duì)乳頭高度及直徑，采血測(cè)定血清中雌激素和孕激素水平，取胸前第1、2對(duì)乳房乳腺、胸腺、脾臟、子宮卵巢稱(chēng)重，計(jì)算臟器系數(shù)；并將乳腺、子宮及卵巢置于10％甲醛溶液中固定，做病理組織檢查。結(jié)果：乳舒片可改善乳腺增生病大鼠乳腺的組織形態(tài)學(xué)結(jié)構(gòu)，縮小乳頭大小和乳腺體積，減少乳腺小葉腺泡數(shù)、腺泡腔、分泌物，并可使血清雌激素水平降低（P＜0.01）。結(jié)論：乳舒片可能通過(guò)調(diào)節(jié)乳腺增生大鼠的性激素水平，改善增生乳腺的形態(tài)學(xué)變化而有效地對(duì)抗雌激素引起的大鼠乳腺增生。

Objective: To study the effects of Rushu Tablet on estrogen, progesterone and pathological change of mammary tissue in hyperplasia of mammary gland and hormone of rats. Methods: The hyperplasia of mammary gland model was induced by Estradiol benzoate intraperitoneal injection in SD female rats once every two days for six weeks. The model rats were treated with low, middle, and high dosages of Rushu Tablet, respectively. To kill all rats after 4 weeks, determinate the level of estrogen, weight organs, and organ coefficient, and observe the tissue of mammary glands. Results: Rushu Tablet could be used for improving the morphological structure of mammary, shortening the papilla and lobule of mammary gland size, diminishing alveoli, Acinar cavity and secretion, reducing the level of estrogen in hyperplasia mammary gland rats (P < 0.05). Conclusion: Rushu Tablet could inhibit mammary gland hyperplasia whose mechanism may base on the regulating of hormone in hyperplasia of mammary gland rats.