目的 探討阿司匹林腸溶片聯(lián)合鹽酸拉貝洛爾治療妊娠期高血壓的臨床療效。方法 選取2016年5月—2018年8月于涼山州第一人民醫(yī)院收治的妊娠期高血壓患者240例作為研究對(duì)象，隨機(jī)將患者分為對(duì)照組和治療組，每組各120例。對(duì)照組患者靜脈滴注鹽酸拉貝洛爾注射液，50 mg溶于5%葡萄糖注射液250 mL中，充分混合，維持劑量為2 mg/min。當(dāng)血壓控制良好并且低于140/90 mmHg時(shí)患者口服鹽酸拉貝洛爾片，100 mg/次，3次/d。治療組患者在對(duì)照組治療的基礎(chǔ)上口服阿司匹林腸溶片，50 mg/d，1次/d。兩組患者持續(xù)治療到妊娠前1 d停用。觀察兩組患者的臨床療效，同時(shí)比較兩組治療前后的血壓和妊娠結(jié)局。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為80.83%、96.67%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者的收縮壓和舒張壓均顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療后治療組血壓低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組胎兒存活率分別為93.33%、100.00%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 阿司匹林腸溶片聯(lián)合鹽酸拉貝洛爾治療妊娠期高血壓具有較好的臨床療效，可改善患者血壓和妊娠結(jié)局，值得臨床推廣使用。

Objective To investigate the clinical efficacy of Aspirin Enteric-coated Tablets combined with labetalol hydrochloride in treatment of gestational hypertension. Methods Patients (240 cases) with gestational hypertension in the First People's Hospital of Liangshan Prefecture from May 2016 to August 2018 were randomly divided into control and treatment groups, and each group had 120 cases. Patients in the control group were iv administered with Labetalol Hydrochloride Injection, 50 mg added into 5% glucose injection 250 mL, and maintenance dose was 2 mg/min. And patients were po administered with Labetalol Hydrochloride Tablets, 100 mg/time, three times daily, when blood pressure was well controlled and lower than 140/90 mmHg. Patients in the treatment group were po administered with Aspirin Enteric-coated Tablets, 50 mg/d, once daily. Patients in two groups were discontinued 1 d before pregnancy. After treatment, the clinical efficacies were evaluated, the blood pressure and pregnancy outcome in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.83% and 96.67%, respectively, and there was difference between two groups (P<0.05). After treatment, the systolic and diastolic blood pressures in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And blood pressures in the treatment group after treatment were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the livability in the control and treatment groups were 93.33% and 100.00%, respectively, and there was difference between two groups (P<0.05). Conclusion Aspirin Enteric-coated Tablets combined with labetalol hydrochloride has clinical curative effect in treatment of gestational hypertension, can improve the blood pressure and pregnancy outcome of patients, which has a certain clinical application value.