目的 觀察小兒金翹顆粒聯(lián)合鹽酸克林霉素棕櫚酸酯干混懸劑治療小兒急性扁桃體炎的有效性和安全性。方法 選取2014年6月—2017年6月在漯河市中心醫(yī)院治療的120例急性扁桃體炎患兒作為研究對(duì)象，所有患兒按照入院先后順序分成對(duì)照組和治療組，每組各60例。對(duì)照組患兒溫水沖服鹽酸克林霉素棕櫚酸酯干混懸劑，1袋/次，3次/d；治療組患者在對(duì)照組治療的基礎(chǔ)上開水沖服小兒金翹顆粒，5～7歲兒童7.5 g/次，3次/d；8～10歲兒童7.5 g/次，4次/d；11～12歲兒童10 g/次，3次/d。兩組患兒連續(xù)治療1周。觀察兩組患者的臨床療效，同時(shí)比較兩組治療前后的癥狀積分、主觀生活質(zhì)量問卷（ISLQ）評(píng)分、視覺模擬評(píng)分法（VAS）、炎性指標(biāo)水平和不良反應(yīng)情況。結(jié)果 治療后，治療組的總有效率為96.67%，顯著高于對(duì)照組的85.00%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者癥狀積分、ISLQ評(píng)分和VAS評(píng)分均顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組癥狀積分、ISLQ評(píng)分和VAS評(píng)分顯著低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血清降鈣素原（PCT）、白細(xì)胞介素-6（IL-6）和C反應(yīng)蛋白（CRP）水平均顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組炎性指標(biāo)水平顯著低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療期間，對(duì)照組和治療組的不良反應(yīng)發(fā)生率分別為13.33%、3.33%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 小兒金翹顆粒聯(lián)合鹽酸克林霉素棕櫚酸酯干混懸劑治療小兒急性扁桃體炎療效顯著，可顯著改善患兒體內(nèi)炎癥水平，安全性高，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the efficacy and safety of Xiaoer Jinqiao Granules combined with Clindamycin Palmitate Hydrochloride for suspension in treatment of acute tonsillitis in children. Methods Children (120 cases) with acute tonsillitis in Luohe Central Hospital from June 2014 to June 2017 were randomly divided into control and treatment groups according to the order of admission, and each group had 60 cases. Children in the control group were po administered with Clindamycin Palmitate Hydrochloride for suspension with warm water, 1 bag/time, three times daily. Children in the treatment group were po administered with Xiaoer Jinqiao Granules on the basis of the control group, 7.5 g/time for children aged 5 - 7 years, three times daily, 7.5 g/time for children aged 8 - 10 years, four times daily, 10 g/time for children aged 11 - 12 years, three times daily. Children in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the symptom scores, ISLQ scores, VAS, inflammatory index levels, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the treatment group was 96.67%, which was significantly higher than 85.00% in the control group, and there were differences between two groups (P<0.05). After treatment, the symptom scores, ISLQ scores, and VAS in two groups were significantly decreased, and there were differences in the same group (P<0.05). And the symptom scores, ISLQ scores, and VAS in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of PCT, IL-6, and CRP in two groups were significantly decreased, and there were differences in the same group (P<0.05). And the inflammatory index levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). The incidence of adverse reactions in the control and treatment groups were 13.33% and 3.33%, respectively, and there were differences between two groups (P<0.05). Conclusion Xiaoer Jinqiao Granules combined with Clindamycin Palmitate Hydrochloride for suspension has good effect in treatment of acute tonsillitis in children, can significantly improve the inflammation level, with high safety, which has a certain clinical application value.